2. Gene
  3. API5 - apoptosis inhibitor 5 Gene

API5 - apoptosis inhibitor 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：凋亡抑制因子 5

种属: Homo sapiens

同用名: AAC11; AAC-11

基因 ID: 8539 | 基因类型: protein coding

关于 API5

Cytogenetic location: 11p12 Genomic coordinates (GRCh38): 11:43,311,996-43,344,529 (from NCBI)

This gene has 11 transcripts (splice variants) and 213 orthologues. Ubiquitous expression in thyroid (RPKM 18.0), lymph node (RPKM 15.7) and 25 other tissues.

功能概要

该基因编码一种凋亡抑制蛋白，其表达可防止生长因子剥夺后的细胞凋亡。这种蛋白质抑制转录因子 E2F1 诱导的细胞凋亡，还与 Acinus 相互作用并负向调节 Acinus，Acinus 是一种参与凋亡 DNA 片段化的核因子。它的消耗增强了化疗药物的细胞毒作用。已经鉴定出编码不同同种型的多个选择性剪接的转录物变体。[RefSeq 提供，2011 年 8 月]

This gene encodes an Apoptosis inhibitory protein whose expression prevents Apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced Apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

API5 基因产物(4)

mRNA Protein Name
NM_001142930.2 NP_001136402.1 apoptosis inhibitor 5 isoform a
NM_001142931.2 NP_001136403.1 apoptosis inhibitor 5 isoform c
NM_001243747.2 NP_001230676.1 apoptosis inhibitor 5 isoform d
NM_006595.4 NP_006586.1 apoptosis inhibitor 5 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables fibroblast growth factor binding IPI
IPI: 通过物理相互作用推断
11075807 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19387494 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
11075807 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
11075807 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

API5 蛋白结构

API5

API5: Apoptosis inhibitory protein 5 (API5) (4 - 516)

  • 0
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  • 200
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  • 400
  • 524 a.a.
蛋白主名 其他名称

apoptosis inhibitor 5

FIF

API5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
API5 Q9BZZ5 DDX39B Homo sapiens Q13838
Crosslink
30021884
种属内
API5 Q9BZZ5 ACIN1 Homo sapiens Q9UKV3-3
Anti Tag CoIP
19387494
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Asbestos-Related Lung Carcinoma
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00819 API5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta API5 VGNC VGNC:99544
Bos taurus API5 VGNC VGNC:26015
Canis familiaris API5 VGNC VGNC:37985
Felis catus API5 VGNC VGNC:67744
Rattus norvegicus API5 RGD RGD:1309772
Mus musculus API5 MGD MGI:1888993
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