Nbn - nibrin Gene

种属: Rattus norvegicus

同用名: Nbs1

关于 Nbn

功能概要

Predicted to enable DNA-binding transcription factor binding activity; damaged DNA binding activity; and protein N-terminus binding activity. Involved in several processes, including negative regulation of neuron differentiation; negative regulation of viral entry into host cell; and regulation of fibroblast proliferation. Predicted to be located in chromosome and nucleus. Predicted to be part of Mre11 complex. Predicted to colocalize with chromosome, telomeric region. Human ortholog(s) of this gene implicated in several diseases, including Nijmegen breakage syndrome; acute lymphoblastic leukemia; aplastic anemia; breast cancer; and reproductive organ Cancer (multiple). Orthologous to human NBN (nibrin). [provided by Alliance of Genome Resources, Apr 2022]