2. Gene
  3. EIF4G3 - eukaryotic translation initiation factor 4 gamma 3 Gene

EIF4G3 - eukaryotic translation initiation factor 4 gamma 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：真核翻译起始因子 4 伽玛 3

种属: Homo sapiens

同用名: eIF4G 3; eIF4GII; eIF-4G 3

基因 ID: 8672 | 基因类型: protein coding

关于 EIF4G3

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:20,806,292-21,176,897 (from NCBI)

This gene has 23 transcripts (splice variants), 230 orthologues and 2 paralogues. Broad expression in testis (RPKM 35.2), thyroid (RPKM 16.6) and 23 other tissues.

功能概要

该基因编码的蛋白质被认为是 eIF4F 蛋白复合物的一部分，它参与 mRNA 帽识别和将 mRNA 转运至核糖体。有趣的是，已发现一种 MicroRNA (miR-520c-3p) 负向调节编码蛋白质的合成，这导致蛋白质翻译和细胞增殖的整体减少。因此，该蛋白是 miR-520c-3p 抗肿瘤活性的关键组分。[RefSeq 提供，2016 年 5 月]

The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a MicroRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]

EIF4G3 基因产物(20)

mRNA Protein Name
NM_001198801.2 NP_001185730.1 eukaryotic translation initiation factor 4 gamma 3 isoform 1
NM_001198802.2 NP_001185731.1 eukaryotic translation initiation factor 4 gamma 3 isoform 2
NM_001198803.2 NP_001185732.1 eukaryotic translation initiation factor 4 gamma 3 isoform 4
NM_001391892.1 NP_001378821.1 eukaryotic translation initiation factor 4 gamma 3 isoform 3
NM_001391893.1 NP_001378822.1 eukaryotic translation initiation factor 4 gamma 3 isoform 3
NM_001391894.1 NP_001378823.1 eukaryotic translation initiation factor 4 gamma 3 isoform 3
NM_001391895.1 NP_001378824.1 eukaryotic translation initiation factor 4 gamma 3 isoform 5
NM_001391896.1 NP_001378825.1 eukaryotic translation initiation factor 4 gamma 3 isoform 6
NM_001391897.1 NP_001378826.1 eukaryotic translation initiation factor 4 gamma 3 isoform 7
NM_001391898.1 NP_001378827.1 eukaryotic translation initiation factor 4 gamma 3 isoform 8
NM_001391899.1 NP_001378828.1 eukaryotic translation initiation factor 4 gamma 3 isoform 9
NM_001391900.1 NP_001378829.1 eukaryotic translation initiation factor 4 gamma 3 isoform 9
NM_001391901.1 NP_001378830.1 eukaryotic translation initiation factor 4 gamma 3 isoform 10
NM_001391902.1 NP_001378831.1 eukaryotic translation initiation factor 4 gamma 3 isoform 11
NM_001391903.1 NP_001378832.1 eukaryotic translation initiation factor 4 gamma 3 isoform 11
NM_001391904.1 NP_001378833.1 eukaryotic translation initiation factor 4 gamma 3 isoform 12
NM_001391905.1 NP_001378834.1 eukaryotic translation initiation factor 4 gamma 3 isoform 13
NM_001391906.1 NP_001378835.1 eukaryotic translation initiation factor 4 gamma 3 isoform 14
NM_001391907.1 NP_001378836.1 eukaryotic translation initiation factor 4 gamma 3 isoform 15
NM_003760.4 NP_003751.2 eukaryotic translation initiation factor 4 gamma 3 isoform 3
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
20212144 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
NOT involved in negative regulation of autophagy IMP
IMP: 通过突变表型推断
18426977 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EIF4G3 蛋白结构

MIF4G

MIF4G: MIF4G domain (756 - 981)

MA3

MA3: MA3 domain (1222 - 1333)

W2

W2: eIF4-gamma/eIF5/eIF2-epsilon (1505 - 1584)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1585 a.a.
蛋白主名 其他名称

eukaryotic translation initiation factor 4 gamma 3

eIF-4-gamma 3

关联疾病

疾病名称 别名
Bardet-Biedl Syndrome 9

BBS9

Bardet-Biedl Syndrome, Type 9
Vulto-Van Silfhout-De Vries Syndrome

Vulto-Van Silfout-De Vries Syndrome

VSVS

Intellectual Developmental Disorder With Impaired Expressive Speech And Behavioral Abnormalities, With Or Without Seizures

Iddisbas

Mrd24

Mental Retardation, Autosomal Dominant 24

Autosomal Dominant Mental Retardation 24

Autosomal Dominant Non-Syndromic Intellectual Disability 24

Mental Retardation, Autosomal Dominant, Type 24
Mouth Disease

Mouth Diseases

Mouth Disorders
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04283 EIF4G3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus EIF4G3 VGNC VGNC:28417
Macaca mulatta EIF4G3 VGNC VGNC:99900
Mus musculus EIF4G3 MGD MGI:1923935
Rattus norvegicus EIF4G3 RGD RGD:1311370
Canis familiaris EIF4G3 VGNC VGNC:40290
Felis catus EIF4G3 VGNC VGNC:61796
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