MARCO - macrophage receptor with collagenous structure Gene

中文名称：具有胶原结构的巨噬细胞受体

种属: Homo sapiens

同用名: SR-A6; SCARA2

关于 MARCO

功能概要

该基因编码的蛋白质是 A 类清道夫受体家族的成员，是先天性抗微生物免疫系统的一部分。该蛋白可以通过细胞外、C 末端、富含半胱氨酸的清道夫受体 (SRCR) 结构域结合革兰氏阴性和革兰氏阳性细菌。除了短的细胞质和跨膜结构域外，还有一个细胞外间隔结构域和一个长的细胞外胶原结构域。蛋白质可以通过三个相同多肽链的胶原结构域的结合形成三聚体分子。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008]