B4GALT2 - beta-1,4-galactosyltransferase 2 Gene

中文名称：β-1,4-半乳糖基转移酶 2

种属: Homo sapiens

同用名: B4Gal-T2; B4Gal-T3; beta4Gal-T2

关于 B4GALT2

功能概要

该基因是七个 beta-1,4-半乳糖基转移酶 (beta4GalT) 基因之一。它们编码 II 型膜结合糖蛋白，这些糖蛋白似乎对供体底物 UDP-半乳糖具有专一性；所有都将半乳糖以 beta1,4 键转移到类似的受体糖：GlcNAc、Glc 和 Xyl。每个 beta4GalT 在不同糖缀合物和糖结构的生物合成中具有独特的功能。作为 II 型膜蛋白，它们具有一个 N 端疏水信号序列，该序列将蛋白质引导至高尔基体，然后保持未切割状态以充当跨膜锚。通过序列相似性，beta4GalTs 形成四组：beta4GalT1 和 beta4GalT2、beta4GalT3 和 beta4GalT4、beta4GalT5 和 beta4GalT6 以及 beta4GalT7。由该基因编码的酶在糖脂和糖蛋白中合成 N-乙酰乳糖胺。其底物特异性受 α-乳清蛋白影响，但不在哺乳期乳腺组织中表达。已发现该基因编码两种不同亚型的三种转录变体。[RefSeq 提供，2011 年 7 月]

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The Enzyme encoded by this gene synthesizes N-acetyllactosamine in glycolipids and glycoproteins. Its substrate specificity is affected by alpha-lactalbumin but it is not expressed in lactating mammary tissue. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]