1. Gene
  2. TNFRSF25 - TNF receptor superfamily member 25 Gene

TNFRSF25 - TNF receptor superfamily member 25 Gene

中文名称:TNF 受体超家族成员 25

种属: Homo sapiens

同用名: DR3; TR3; DDR3; LARD; APO-3; TRAMP; WSL-1; GEF720; WSL-LR; PLEKHG5; TNFRSF12

基因 ID: 8718 | 基因类型: protein coding

关于 TNFRSF25

Cytogenetic location: 1p36.31 Genomic coordinates (GRCh38): 1:6,460,786-6,466,173 (from NCBI)

This gene has 21 transcripts (splice variants), 461 orthologues and 21 paralogues. Broad expression in skin (RPKM 23.6), spleen (RPKM 13.2) and 19 other tissues.

功能概要

由该基因编码的蛋白质是 TNF 受体超家族的成员。该受体优先在富含淋巴细胞的组织中表达,可能在调节淋巴细胞稳态中发挥作用。该受体已被证明可刺激 NF-kappa B 活性并调节细胞凋亡。该受体的信号转导由各种含有衔接蛋白的死亡结构域介导。小鼠基因敲除研究表明该基因在去除胸腺中的自身反应性 T 细胞中的作用。已经报道了编码不同亚型的该基因的多个可变剪接转录物变体,其中大部分是潜在的分泌分子。该基因在 B 细胞和 T 细胞中的可变剪接在 T 细胞激活时遇到程序性变化,它主要产生全长膜结合同种型,并且被认为参与控制由 T 细胞激活诱导的淋巴细胞增殖。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell Apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008]

TNFRSF25 基因产物(6)

mRNA Protein Name
NM_001039664.2 NP_001034753.1 tumor necrosis factor receptor superfamily member 25 isoform 12 precursor
NM_003790.3 NP_003781.1 tumor necrosis factor receptor superfamily member 25 isoform 2 precursor
NM_148965.2 NP_683866.1 tumor necrosis factor receptor superfamily member 25 isoform 1 precursor
NM_148966.2 NP_683867.1 tumor necrosis factor receptor superfamily member 25 isoform 3 precursor
NM_148967.2 NP_683868.1 tumor necrosis factor receptor superfamily member 25 isoform 4 precursor
NM_148970.2 NP_683871.1 tumor necrosis factor receptor superfamily member 25 isoform 7 precursor
基因本体论
  • 细胞组分
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
11911831 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TNFRSF25 蛋白结构

Death

Death: Death domain (334 - 411)

  • 0
  • 100
  • 200
  • 300
  • 417 a.a.
蛋白主名 其他名称

tumor necrosis factor receptor superfamily member 25

Guanine nucleotide exchange factor 720

重组 TNFRSF25 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72666 DR3/TNFRSF25 Protein, Human (HEK293, Fc) Q93038 (Q25-F201) ≥95%
HY-P77522 DR3/TNFRSF25 Protein, Human (Biotinylated, HEK293, Fc) Q93038 (Q25-Q199) ≥95%

关联疾病

疾病名称 别名
Type 1 Diabetes Mellitus 5

Diabetes Mellitus, Insulin-Dependent, 5

Latent Autoimmune Diabetes In Adults

IDDM5

Insulin-Dependent Diabetes Mellitus 5

T1D5

Lada

Type 1.5 Diabetes

Diabetes Mellitus, Insulin-Dependent, Type 5

Pemphigoid Gestationis

Herpes Gestationis

Gestational Pemphigoid

Gestational Herpes

Autoimmune Disease Of Endocrine System
Adrenal Cortical Hypofunction

Adrenal Cortical Insufficiency

Corticoadrenal Insufficiency

Juvenile Dermatitis Herpetiformis
Amelogenesis Imperfecta, Type Ib

AI1B

Aih2

Amelogenesis Imperfecta Type 1b

Amelogenesis Imperfecta Type Ib

Hereditary Localized Enamel Hypoplasia

Amelogenesis Imperfecta - Hypoplastic Autosomal Dominant - Local

Amelogenesis Imperfecta, Hypoplastic Local, Autosomal Dominant

Enamel Hypoplasia, Hereditary Localized

Autosomal Dominant Hypoplastic Local Amelogenesis Imperfecta

Amelogenesis Imperfecta 1b

Amelogenesis Imperfecta Hypoplastic 2

Amelogenesis Imperfecta Hypoplastic Local Autosomal Dominant

Amelogenesis Imperfecta, Type Ie

Aih1

Amelogenesis Imperfecta Type 1e

AI1E

Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 1

Amelogenesis Imperfecta, Hypomaturation Type, With Snow-Capped Teeth

Enamel Hypoplasia, X-Linked

Amelogenesis Imperfecta Type Ie

Amelogenesis Imperfecta Hypoplastic/Hypomaturation X-Linked 1

Enamel Hypoplasia X-Linked

Amelogenesis Imperfecta, X-Linked 1

Amelogenesis Imperfecta, Type 1e

Amelogenesis Imperfecta Hypomaturationtype With Snow-Capped Teeth

X-Linked Amelogenesis Imperfecta 1

X-Linked Amelogenesis Imperfecta Hypoplastic/Hypomaturation 1

X-Linked Enamel Hypoplasia

Amelogenesis Imperfecta X-Linked 1

Amelogenesis Imperfecta 1e

Amelogenesis Imperfecta, Hypoplastic/Hypomaturation Type 1e

Amelogenesis Imperfecta Hypomaturation Type With Snow-Capped Teeth

Xai

X-Linked Amelogenesis Imperfecta

Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 2

Thyroiditis

Inflammation Of Thyroid

Thyroiditis Nos

Haemophilus Meningitis

Meningitis, Haemophilus

Type 1 Diabetes Mellitus 17

Diabetes Mellitus, Insulin-Dependent, 17

Iddm17

Insulin-Dependent Diabetes Mellitus 17

TID17

Insulin-Dependent Diabetes Mellitus-17

Heart Block, Congenital

Congenital Heart Block

Heart Block Congenital

Congenital Atrioventricular Block

Type 1 Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent

Diabetes Mellitus Type 1

IDDM

Type 1 Diabetes

Insulin-Dependent Diabetes Mellitus

T1D

Juvenile-Onset Diabetes

Jod

Diabetes Mellitus, Type 1

Diabetes Mellitus, Insulin-Dependent-1

Type I Diabetes Mellitus

Autoimmune Diabetes

Juvenile Diabetes

Juvenile-Onset Diabetes Mellitus

Diabetes, Insulin Dependent

Insulin-Dependent Diabetes Mellitus-1

Diabetes Mellitus Insulin-Dependent

Diabetes Autoimmune

Diabetes Mellitus, Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 1, Susceptibility To

Diabetes Type 1

Type I Diabetes

Diabetes, Autoimmune

T1dm - [Type 1 Diabetes Mellitus]

Iddm - [Insulin Dependent Diabetes Mellitus]

Type 1 Iddm

Juvenile Diabetes Mellitus Without Compications

Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications

Juvenile-Onset Diabetes Mellitus Without Compications

Ketosis-Prone Diabetes Mellitus Without Compications

Juvenile-Onset-Type Diabetes Mellitus Without Compications

Immunoglobulin Alpha Deficiency

Iga Deficiency

Gamma-A-Globulin Deficiency

Immunoglobulin A Deficiency

Autoimmune Polyendocrine Syndrome, Type Ii

Schmidt Syndrome

Autoimmune Polyendocrine Syndrome Type 2

APS2

Autoimmune Polyglandular Syndrome Type 2

Diabetes Mellitus, Addison Disease, Myxedema

Polyglandular Autoimmune Syndrome, Type Ii

Pga Ii

Polyendocrine Autoimmune Syndrome, Type Ii

Aps Ii

Autoimmune Polyglandular Syndrome Type Ii

Diabetes Mellitus, Addison'S Disease, Myxedema

Multiple Endocrine Deficiency Syndrome, Type 2

Pga 2

Pga-Ii

Polyglandular Autoimmune Syndrome, Type 2

Polyglandular Deficiency Syndrome Type 2

Schmidt'S Syndrome

Autoimmune Polyendocrinopathy Type 2

Aps Type 2

Autoimmune Thyroid Disease And/Or Type 1 Diabetes-Addison Disease Syndrome

Autoimmune Syndrome Type Ii Polyglandular

Autoimmune Syndrome Type Ii, Polyglandular

Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma

Bird Fancier'S Lung

Bird Fancier Lung

Pigeon Breeder'S Lung

Avian Hypersensitivity Pneumonitis

Bird Breeder'S Lung

Bird-Fancier'S Lung

Bird-Fanciers' Lung

Poultry Worker'S Lung

Pigeon-Breeder Lung Disease

Pigeon Breeders Lung

Avian Protein Hypersensitivity

Bird Breeders' Disease

Bird Breeders' Lung

Bird Fanciers' Lung

Bird Fanciers' Disease

Bfl - [Bird Fancier Lung]

Fanciers' Disease

Fanciers' Lung

Immunoglobulin A Deficiency 1

Immunoglobulin A Deficiency

Selective Iga Deficiency Disease

Selective Immunoglobulin A Deficiency

IGAD1

Immunoglobulin A, Selective Deficiency Of

Iga, Selective Deficiency Of

Gamma-A-Globulin, Selective Deficiency Of

Selective Iga Immunodeficiency

Selective Iga Deficiency

Iga Deficiency Selective

Robinow Syndrome, Autosomal Dominant 1

Autosomal Dominant Robinow Syndrome 1

DRS1

Robinow Dwarfism

Fetal Face Syndrome

Acral Dysostosis With Facial And Genital Abnormalities

Robinow, Autosomal Dominant Syndrome, Type 1

Parotid Disease

Parotid Diseases

Pernicious Anemia

Anemia, Pernicious

Anemia Pernicious

Pernicious Anaemia

Addison'S Anaemia

Biermer'S Anaemia

Biermer'S Anemia

Acquired Pernicious Anemia

Addison-Biermer Anemia

Addisonian Anemia

Biermer Anemia

Biermer'S Disease

Juvenile Onset Pernicious Anemia

Biermer Disease

Biermer-Addison Disease

Punctate Epithelial Keratoconjunctivitis

Punctate Keratitis

Thygeson Superficial Punctate Keratitis

Thygeson'S Superficial Punctate Keratitis

Thygeson Superficial Punctate Keratopathy

Punctate Epithelial Keratitis

Autoimmune Disease Of Gastrointestinal Tract
Celiac Disease 1

Celiac Disease

Coeliac Disease

Celiac Sprue

Celiac Disease, Susceptibility To

Gluten-Sensitive Enteropathy

Nontropical Sprue

Sprue

CELIAC1

Celiac Disease, Susceptibility To, 1

Celiac Sprue 1

Celiac Sprue, Susceptibility To, 1

Gluten-Sensitive Enteropathy 1

Gluten-Sensitive Enteropathy, Susceptibility To, 1

Idiopathic Steatorrhea

Cœliac Disease

Gluten Intolerance

Gluten-Induced Enteropathy

Gluten Enteropathy

Celiac Disease, Susceptibility To, Type 1

Childhood Celiac Disease

Coeliac Rickets

Gee Disease

Gee-Herter Disease

Heubner-Herter Disease

Idiopathic Steatorrhoea

Thaysen'S Disease

Herter Gee Syndrome

Lymphocytic Colitis

Colitis, Lymphocytic

Type 1 Diabetes Mellitus 15

Diabetes Mellitus, Insulin-Dependent, 15

Iddm15

Insulin-Dependent Diabetes Mellitus 15

T1D15

Insulin-Dependent Diabetes Mellitus-15

Adrenal Cortex Disease

Adrenal Cortex Diseases

Lymphoid Interstitial Pneumonia

Lymphocytic Interstitial Pneumonia

Lip Disease

Lip Diseases

LIP

Disease Of Lips

Sclerosing Cholangitis

Fibrosing Cholangitis

Cholangitis, Sclerosing

Primary Sclerosing Cholangitis

Hashimoto Thyroiditis

Autoimmune Thyroiditis

Hashimoto Struma

Hashimoto'S Thyroiditis

Chronic Lymphocytic Thyroiditis

Lymphocytic Thyroiditis

Hashimoto Disease

Ht

Hashimoto'S Disease

Hashimoto'S Syndrome

Hypothyroidism, Autoimmune

Autoimmune Chronic Lymphocytic Thyroiditis

Chronic Lymphocytic Thyroiditides

Hashimoto Syndrome

Hashimotos Thyroiditis

Hashimoto Thyroiditis, Susceptibility To

Thyroiditis, Autoimmune

Lymphomatous Thyroiditis

Lymphoid Thyroiditis

Chronic Lymphadenoid Thyroiditis

Autoimmune Lymphocytic Chronic Thyroiditis

Goitre Lymphomatosa

Hashitoxicosis

Hashimoto Hypothyroidism

Lymphadenoid Goitre

Struma Lymphomatosa

Hyperthyroidism With Hashimoto Disease

Hashimoto Thyrotoxicosis

Thyrotoxicosis Due To Hashimoto Thyroiditis

Struma Lymphomatosis

Lymphadenoid Struma

Type 1 Diabetes Mellitus 12

Diabetes Mellitus, Insulin-Dependent, 12

IDDM12

Insulin-Dependent Diabetes Mellitus 12

T1D12

Type 1 Diabetes Mellitus 12, Susceptibility To

Diabetes Mellitus, Insulin-Dependent, Type 12

Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis

PSC

Sclerosing Cholangitis

Cholangitis, Sclerosing

Cholangitis Primary Sclerosing

Psc - [Primary Sclerosing Cholangitis]

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Invasive Malignant Thymoma

Infiltrating Thymoma

Thymoma Malignant Invasive

Invasive Thymoma And Thymic Carcinoma

Diabetes Mellitus

Diabetes

Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome

Chromosome 11p11.2 Deletion Syndrome

Pss

11p11.2 Deletion

P11pds

Defect11 Syndrome

Deletion Of Chromosome 11p11.2

POSHS

Primary Biliary Cholangitis

Primary Biliary Cirrhosis

Biliary Liver Cirrhosis

Chronic Nonsuppurative Destructive Cholangitis

Familial Primary Biliary Cirrhosis

Pbc

Hanot Syndrome

Cholestatic Cirrhosis

Biliary Cirrhosis Primary

Liver Cirrhosis, Biliary

Hanot'S Cirrhosis

Biliary Cirrhosis

Pericholangiolic Biliary Cirrhosis

Tannhauser-Magendantz Syndrome

Hanot-Rossle Syndrome

Hypertrophic Cirrhosis

Todd Cirrhosis

Hanot Cirrhosis

Charcot Cirrhosis

Mahon-Tannhauser Syndrome

Toxic Cirrhosis

Hypertrophic Biliary Cirrhosis

Monolobular Cirrhosis

Unilobar Cirrhosis

Xanthomatous Biliary Cirrhosis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus TNFRSF25 MGD MGI:1934667
Rattus norvegicus TNFRSF25 RGD RGD:1598206
Felis catus TNFRSF25 VGNC VGNC:66410
Macaca mulatta TNFRSF25 VGNC VGNC:78584
Canis familiaris TNFRSF25 VGNC VGNC:47664
Bos taurus TNFRSF25 VGNC VGNC:36167
Others TNFRSF25 NCBI