2. Gene
  3. CBR1 - carbonyl reductase 1 Gene

CBR1 - carbonyl reductase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：羰基还原酶 1

种属: Homo sapiens

同用名: CBR; hCBR1; PG-9-KR; SDR21C1

基因 ID: 873 | 基因类型: protein coding

关于 CBR1

Cytogenetic location: 21q22.12 Genomic coordinates (GRCh38): 21:36,070,024-36,073,164 (from NCBI)

This gene has 5 transcripts (splice variants), 362 orthologues and 13 paralogues. Broad expression in duodenum (RPKM 163.2), small intestine (RPKM 98.7) and 19 other tissues.

功能概要

该基因编码的蛋白质属于短链脱氢酶/还原酶 (SDR) 家族，作为 NADPH 依赖性氧化还原酶发挥作用，对羰基化合物具有广泛的特异性，例如醌类、前列腺素和各种异生素。已发现该基因的可变剪接转录物变体。[RefSeq 提供，2013 年 11 月]

The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as Quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]

CBR1 基因产物(2)

mRNA Protein Name
NM_001286789.2 NP_001273718.1 carbonyl reductase [NADPH] 1 isoform 2
NM_001757.4 NP_001748.1 carbonyl reductase [NADPH] 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables carbonyl reductase (NADPH) activity IDA
IDA: 通过直接分析推断
1921984 GOA
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IDA
IDA: 通过直接分析推断
19442656 GOA
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IDA
IDA: 通过直接分析推断
28878267 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
26496610 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in epithelial cell differentiation IEP
IEP: 通过表达模式推断
21492153 GOA
involved in glucocorticoid metabolic process IDA
IDA: 通过直接分析推断
28878267 GOA
involved in positive regulation of reactive oxygen species metabolic process IDA
IDA: 通过直接分析推断
19442656 GOA
involved in vitamin K metabolic process IDA
IDA: 通过直接分析推断
18449627 GOA
involved in xenobiotic metabolic process IDA
IDA: 通过直接分析推断
18449627 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CBR1 蛋白结构

adh_short

adh_short: short chain dehydrogenase (7 - 146)

  • 0
  • 100
  • 200
  • 277 a.a.
蛋白主名 其他名称

carbonyl reductase [NADPH] 1

15-hydroxyprostaglandin dehydrogenase

重组 CBR1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72272 CBR1 Protein, Human (P.pastoris, His) P16152 (S2-W277) ≥95%

关联疾病

疾病名称 别名
Constipation
Down Syndrome

Trisomy 21

Complete Trisomy 21 Syndrome

Down'S Syndrome

Trisomy 21 Syndrome

Down'S Syndrome - Trisomy 21

Downs Syndrome

G Trisomy

47,Xx,+21

47,Xy,+21

Trisomy G

Down Syndrome, Susceptibility To

Chromosome 21 Trisomy

Trisomy 21 Nos

Abnormal Autosomes 21
Depersonalization Disorder

Neurotic Derealization

Depersonalization

Depersonalization/Derealization Disorder

Depersonalisation-Derealization Syndrome

Depersonalisation Disorder

Depersonalisation Neurosis

Depersonalisation Syndrome

Feeling Of Unreality

Feels Own Self Is Unreal

Neurotic State With Depersonalisation

Neurotic State With Depersonalization Episode
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-N0148 Rutin 98.06% 否
Pre-clinical Phase
生物活性分子 (14)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13930 Miquelianin 99.70% 否
HY-N2609 7,4'-Dihydroxyflavone Inhibitor 99.68% 否
HY-156694 Hydroxy-PP-Me Modulator 99.92% 否
HY-155587 Hydroxy-PP 99.66% 否
HY-121710 MonoHER / 否
HY-157444 5,3',4',3'',4'',5''-6-O-Ethyl-EGCG Inhibitor / 否
HY-157445 CBR1-IN-3 / 否
HY-157447 CBR1-IN-4 / 否
HY-157448 CBR1-IN-6 Inducer / 否
HY-157449 CBR1-IN-5 / 否
HY-157450 YF-Mo1 / 否
HY-157451 CBR1-IN-7 / 否
HY-157452 (8S)-Methyl zearalenone Inhibitor / 否
HY-RS02004 CBR1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CBR1 RGD RGD:7631561
Macaca mulatta CBR1 VGNC VGNC:80854
Mus musculus CBR1 MGD MGI:88284
Others CBR1 NCBI
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