2. Gene
  3. ADAM21 - ADAM metallopeptidase domain 21 Gene

ADAM21 - ADAM metallopeptidase domain 21 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ADAM 金属肽酶域 21

种属: Homo sapiens

同用名: ADAM31; ADAM 21

基因 ID: 8747 | 基因类型: protein coding

关于 ADAM21

Cytogenetic location: 14q24.2 Genomic coordinates (GRCh38): 14:70,452,174-70,459,905 (from NCBI)

This gene has 2 transcripts (splice variants), 422 orthologues and 20 paralogues. Biased expression in testis (RPKM 6.0) and brain (RPKM 0.2).

功能概要

该基因编码 ADAM (一种去整合素和金属蛋白酶结构域) 家族的成员。该家族的成员是膜锚定蛋白，在结构上与蛇毒解离蛋白相关，并且涉及涉及细胞-细胞和细胞-基质相互作用的各种生物过程，包括受精、肌肉发育和神经发生。该基因表达的表达是睾丸特异性的。[RefSeq 提供，2011 年 5 月]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The expression of this gene expression is testis-specific. [provided by RefSeq, May 2011]

ADAM21 基因产物(1)

mRNA Protein Name
NM_003813.4 NP_003804.2 disintegrin and metalloproteinase domain-containing protein 21 preproprotein

ADAM21 蛋白结构

Pep_M12B_propep

Pep_M12B_propep: Reprolysin family propeptide (41 - 159)

Reprolysin

Reprolysin: Reprolysin (M12B) family zinc metalloprotease (209 - 398)

Disintegrin

Disintegrin: Disintegrin (415 - 489)

ADAM_CR

ADAM_CR: ADAM cysteine-rich (492 - 607)

  • 0
  • 200
  • 400
  • 600
  • 722 a.a.
蛋白主名 其他名称

disintegrin and metalloproteinase domain-containing protein 21

ADAM metallopeptidase domain 21, preproprotein

ADAM21 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ADAM21 Q9UKJ8 CNR2 Homo sapiens P34972
Y2H Prey Pooling
32296183
种属内
ADAM21 Q9UKJ8 CNR2 Homo sapiens P34972
Y2H Array
32296183
种属内
ADAM21 Q9UKJ8 SGTA Homo sapiens O43765
Y2H Prey Pooling
32296183
种属内
ADAM21 Q9UKJ8 SGTA Homo sapiens O43765
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Intellectual Developmental Disorder With Short Stature And Behavioral Abnormalities

IDDSSBA
Developmental Coordination Disorder

Motor Skills Disorders
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00277 ADAM21 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ADAM21 RGD RGD:6499950
Canis familiaris ADAM21 VGNC VGNC:37579
Bos taurus ADAM21 VGNC VGNC:55030
Mus musculus ADAM21 MGD MGI:1861229
Macaca mulatta ADAM21 VGNC VGNC:103783
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