1. Gene
  2. TNFRSF6B - TNF receptor superfamily member 6b Gene

TNFRSF6B - TNF receptor superfamily member 6b Gene

中文名称:TNF 受体超家族成员 6b

种属: Homo sapiens

同用名: M68; TR6; DCR3; M68E; DJ583P15.1.1

基因 ID: 8771 | 基因类型: protein coding

关于 TNFRSF6B

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:63,696,652-63,698,684 (from NCBI)

This gene has 1 transcript (splice variant), 95 orthologues and 21 paralogues. Broad expression in appendix (RPKM 7.2), spleen (RPKM 3.2) and 20 other tissues.

功能概要

该基因属于肿瘤坏死因子受体超家族。编码的蛋白质被假定在抑制 FasL 和 LIGHT 介导的细胞死亡中发挥调节作用。它充当诱饵受体,与死亡受体竞争配体结合。已在胃肠道肿瘤中注意到该基因的过度表达。从编码端粒延长解旋酶 1 (RTEL1) 调节因子的邻近上游基因通读转录到该基因中,生成非编码转录本。[RefSeq 提供,2011 年 2 月]

This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]

TNFRSF6B 基因产物(1)

mRNA Protein Name
NM_003823.4 NP_003814.1 tumor necrosis factor receptor superfamily member 6B precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10318773 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TNFRSF6B 蛋白结构

TNFR_c6

TNFR_c6: TNFR/NGFR cysteine-rich region (73 - 113)

  • 0
  • 100
  • 200
  • 300 a.a.
蛋白主名 其他名称

tumor necrosis factor receptor superfamily member 6B

decoy receptor for Fas ligand

TNFRSF6B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TNFRSF6B O95407 KRTAP10-9 Homo sapiens P60411 25416956
种属内
TNFRSF6B O95407 KRTAP10-9 Homo sapiens P60411 25416956
种属内
TNFRSF6B O95407 TNFSF15 Homo sapiens O95150-1
SPR
21300286
种属内
TNFRSF6B O95407 TNFSF15 Homo sapiens O95150-1 21300286
种属内
TNFRSF6B O95407 TNFSF14 Homo sapiens O43557-1
SPR
21300286
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 TNFRSF6B 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75306 DcR3/TNFRSF6B Protein, Human (sf9, hFc) O95407 (V30-H300) ≥95%

关联疾病

疾病名称 别名
Caplan'S Syndrome

Caplan Syndrome

Caplan'S Disease

Caplans Syndrome

Rheumatoid Pneumoconiosis

Silicosis

Silicotuberculosis

Acute Silicosis

Chronic Silicosis

Pneumoconiosis Due To Silicates

Silica Pneumoconiosis

Silicotic Fibrosis Of Lung

Accelerated Silicosis

Experimental Silicosis

Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach

Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy

CORD2

Cone-Rod Retinal Dystrophy

Rcrd2

Cone-Rod Retinal Dystrophy 2

Crd2

Cord

Crd

Retinal Cone-Rod Dystrophy

Cone-Rod Retinal Dystrophy-2

Retinal Cone-Rod Dystrophy 2

Tapetoretinal Degeneration

Cone-Rod Degeneration

Cone Rod Dystrophy

Dystrophy, Cone-Rod

Dystrophy, Cone-Rod, Type 2

Retinitis Pigmentosa

Retinitis Pigmentosa 2

Progressive Cone-Rod Dystrophy

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma