TNFRSF18 - TNF receptor superfamily member 18 Gene

中文名称：TNF 受体超家族成员 18

种属: Homo sapiens

同用名: AITR; GITR; CD357; GITR-D; ENERGEN

基因 ID: 8784 | 基因类型: protein coding

关于 TNFRSF18

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,203,508-1,206,592 (from NCBI)

This gene has 4 transcripts (splice variants), 562 orthologues and 21 paralogues. Biased expression in skin (RPKM 4.0), appendix (RPKM 1.0) and 12 other tissues.

功能概要

该基因编码 TNF 受体超家族的一个成员。编码的受体已被证明在 T 细胞激活后表达增加，并且它被认为在 CD25 (+) CD4 (+) 调节性 T 细胞维持的显性免疫自身耐受中发挥关键作用。小鼠基因敲除研究也表明该受体在调节 CD3 驱动的 T 细胞激活和程序性细胞死亡中的作用。已经报道了编码不同同种型的该基因的三种可变剪接转录物变体。[RefSeq 提供，2011 年 2 月]

This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]

TNFRSF18 基因产物(3)

mRNA	Protein	Name
NM_004195.3	NP_004186.1	tumor necrosis factor receptor superfamily member 18 isoform 1 precursor
NM_148901.2	NP_683699.1	tumor necrosis factor receptor superfamily member 18 isoform 2 precursor
NM_148902.2	NP_683700.1	tumor necrosis factor receptor superfamily member 18 isoform 3 precursor

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	18040044	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of cell adhesion	IMP IMP: 通过突变表型推断	23892569	GOA
involved in positive regulation of leukocyte migration	IMP IMP: 通过突变表型推断	23892569	GOA
involved in positive regulation of tyrosine phosphorylation of STAT protein	IMP IMP: 通过突变表型推断	23892569	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

tumor necrosis factor receptor superfamily member 18

TNF receptor superfamily activation-inducible protein

TNFRSF18 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TNFRSF18	Q9Y5U5	TNFSF18	Homo sapiens	Q9UNG2	SPR	18378892

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 TNFRSF18 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70683	GITR Protein, Human (HEK293, hFc)	Q9Y5U5 (Q26-E161)	≥95%
HY-P70822	GITR Protein, Human (T45A, HEK293, mFc)	Q9Y5U5 (Q26-E161, T45A)	≥95%
HY-P73076	GITR Protein, Human (HEK293, His)	Q9Y5U5 (Q26-E161)	≥95%
HY-P75166	GITR Protein, Human (Biotinylated, HEK293, Fc-Avi)	Q9Y5U5 (Q26-E161)	≥95%
HY-P78137	GITR Protein, Human (Biotinylated, HEK293, His-Avi)	Q9Y5U5 (Q26-E161)	≥95%

关联疾病

疾病名称

别名

Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked

IPEX	X-Linked Autoimmunity-Allergic Dysregulation Syndrome
Xlaad	Diarrhea, Polyendocrinopathy, Fatal Infection Syndrome, X-Linked
Ipex Syndrome	Insulin-Dependent Diabetes Mellitus Secretory Diarrhea Syndrome
Iddm-Secretory Diarrhea Syndrome	Dmsd
Autoimmunity-Immunodeficiency Syndrome, X-Linked	Enteropathy, Autoimmune, With Hemolytic Anemia And Polyendocrinopathy
Xpid	Diabetes Mellitus, Congenital Insulin-Dependent, With Fatal Secretory Diarrhea
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome	Polyendocrinopathy, Immune Dysfunction, And Diarrhea, X-Linked
Autoimmune Enteropathy Type 1	Immunodeficiency, Polyendocrinopathy, And Enteropathy, X-Linked
Immunodeficiency, Polyendocrinopathy, And Enteropathy, X-Linked, Formerly	Immunodeficiency, Polyendocrinopathy, Enteropathy X-Linked Syndrome
Immunodysregulation, Polyendocrinopathy And Enteropathy X-Linked	Autoimmunity-Immunodeficiency Syndrome X-Linked
Iddm Secretory Diarrhea Syndrome	Polyendocrinopathy, Immune Dysfunction And Diarrhea X-Linked
Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome	Immunodeficiency Polyendocrinopathy, Enteropathy, X-Linked Syndrome
X-Linked Autoimmunity-Immunodeficiency Syndrome	Immunodeficiency, Polyendocrinopathy, And Enteropathy X-Linked Syndrome
X-Linked Syndrome Of Polyendocrinopathy, Immune Dysfunction, And Diarrhea

Diverticulitis

Immunodeficiency 41 With Lymphoproliferation And Autoimmunity

Cd25 Deficiency	Immunodeficiency Due To Cd25 Deficiency
IMD41	Interleukin 2 Receptor, Alpha, Deficiency Of
Il2ra Deficiency	Immunodeficiency 41
Interleukin-2 Receptor Alpha Chain Deficiency	Interleukin 2 Receptor Alpha Deficiency
Interleukin-2 Receptor, Alpha Chain, Deficiency Of	Immunodeficiency, Type 41 With Lymphoproliferation And Autoimmunity

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Common Variable Immunodeficiency

Cvid	Common Variable Agammaglobulinemia
Common Variable Immune Deficiency	Acquired Hypogammaglobulinemia
Hypogamma-Globulinemia, Acquired	Idiopathic Immunoglobulin Deficiency
Primary Antibody Deficiency	Primary Hypogammaglobulinemia
Acquired Agammaglobulinemia	Sporadic Hypogammaglobulinemia
Common Variable Hypogamma-Globulinemia	Immunoglobulin Deficiency, Late-Onset
Common Variable Hypogammaglobulinemia	Immunodeficiency, Common Variable

Dermatitis, Atopic, 7

ATOD7	Dermatitis, Atopic, Susceptibility To, 7
Atopic Dermatitis 7	Dermatitis, Atopic 7

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Parotid Gland Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Parotid Gland

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14808	TNFRSF18 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	TNFRSF18	MGD	MGI:894675
Macaca mulatta	TNFRSF18	VGNC	VGNC:78587
Rattus norvegicus	TNFRSF18	RGD	RGD:1565872
Canis familiaris	TNFRSF18	VGNC	VGNC:47660
Felis catus	TNFRSF18	VGNC	VGNC:66406
Bos taurus	TNFRSF18	VGNC	VGNC:36163
Macaca fascicularis	TNFRSF18	NCBI	NCBI:102146362
Others	TNFRSF18	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TNFRSF18 - TNF receptor superfamily member 18 Gene

关于 TNFRSF18

功能概要

TNFRSF18 基因产物(3)

TNFRSF18 蛋白互作信息

重组 TNFRSF18 蛋白

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

TNFRSF18 - TNF receptor superfamily member 18 Gene

关于 TNFRSF18

功能概要

TNFRSF18 基因产物(3)

TNFRSF18 蛋白互作信息

重组 TNFRSF18 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z