2. Gene
  3. IL18RAP - interleukin 18 receptor accessory protein Gene

IL18RAP - interleukin 18 receptor accessory protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：白细胞介素 18 受体辅助蛋白

种属: Homo sapiens

同用名: ACPL; CD218b; IL-1R7; IL18RB; CDw218b; IL-1R-7; IL-18RAcP; IL-1RAcPL; IL-18Rbeta; IL-18R-beta

基因 ID: 8807 | 基因类型: protein coding

关于 IL18RAP

Cytogenetic location: 2q12.1 Genomic coordinates (GRCh38): 2:102,418,621-102,452,565 (from NCBI)

This gene has 5 transcripts (splice variants), 161 orthologues and 10 paralogues. Biased expression in bone marrow (RPKM 26.2), appendix (RPKM 5.0) and 4 other tissues.

功能概要

该基因编码的蛋白质是白介素 18 (IL18) 异二聚体受体的辅助亚基，IL18 是一种参与诱导细胞介导免疫的促炎细胞因子。该蛋白增强了 IL18 受体的 IL18 结合活性，并在 IL18 的信号传导中发挥作用。该基因的突变与克罗恩病和炎症性肠病以及对乳糜泻和麻风病的易感性有关。已经描述了该基因的选择性剪接转录物变体，但它们的全长性质尚不清楚。[RefSeq 提供，2014 年 2 月]

The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]

IL18RAP 基因产物(5)

mRNA Protein Name
NM_001393486.1 NP_001380415.1 interleukin-18 receptor accessory protein isoform 1 precursor
NM_001393487.1 NP_001380416.1 interleukin-18 receptor accessory protein isoform 1 precursor
NM_001393488.1 NP_001380417.1 interleukin-18 receptor accessory protein isoform 2
NM_001393489.1 NP_001380418.1 interleukin-18 receptor accessory protein isoform 2
NM_003853.4 NP_003844.1 interleukin-18 receptor accessory protein isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables coreceptor activity IDA
IDA: 通过直接分析推断
25500532 GOA
enables interleukin-18 receptor activity IDA
IDA: 通过直接分析推断
25500532 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in interleukin-18-mediated signaling pathway IDA
IDA: 通过直接分析推断
25500532 GOA
involved in positive regulation of NF-kappaB transcription factor activity IDA
IDA: 通过直接分析推断
25500532 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of interleukin-18 receptor complex IDA
IDA: 通过直接分析推断
25500532 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IL18RAP 蛋白结构

Ig_2

Ig_2: Immunoglobulin domain (177 - 228)

Ig_2

Ig_2: Immunoglobulin domain (262 - 352)

TIR

TIR: TIR domain (410 - 558)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 599 a.a.
蛋白主名 其他名称

interleukin-18 receptor accessory protein

CD218 antigen-like family member B

IL18RAP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
IL18RAP O95256 WFS1 Homo sapiens O76024
Y2H Array
32814053
种属内
IL18RAP O95256 WFS1 Homo sapiens O76024
Validated Y2H
32814053
种属内
IL18RAP O95256 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 IL18RAP 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72573 IL-18R beta/IL-1R7 Protein, Human (HEK293, His) O95256 (F20-R356) ≥95%
HY-P76425 IL-18R beta/IL-1R7 Protein, Human (HEK293, Fc) O95256-1 (F20-G357) ≥95%

关联疾病

疾病名称 别名
Crohn'S Disease

Crohn Disease

Pediatric Crohn'S Disease

Regional Enteritis

Crohn'S Disease Of Large Bowel

Granulomatous Colitis

Enteritis, Granulomatous

Enteritis

Crohn'S Disease Of Colon

Colitis, Granulomatous

Crohn'S Enteritis

Enteritis, Regional

Ileitis

Adenoviral Enteritis

Acute Gastroenteropathy Due To Norwalk Agent

Viral Gastroenteritis Due To Norwalk Agent

Winter Vomiting

Epidemic Winter Vomiting Disease

Small Round Structured Virus Enteritis

Epidemic Vomiting Syndrome

Epidemic Vomiting

Epidemic Nausea

Epidemic Viral Gastroenteritis Due To Norwalk Virus

Noroviral Enteritis

Crohn Disease Nos

Crohns

Cd - [Crohn'S Disease]

Regional Enteritis Of Bowel

Crohn'S Regional Enteritis

Cobble-Stone Appearance Of Intestine

Intestinal Ulcer And Erosion Due To Crohn Disease

Granulomatous Enteritis
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Inflammatory Bowel Disease 5

IBD5
Celiac Disease 1

Celiac Disease

Coeliac Disease

Celiac Sprue

Celiac Disease, Susceptibility To

Gluten-Sensitive Enteropathy

Nontropical Sprue

Sprue

CELIAC1

Celiac Disease, Susceptibility To, 1

Celiac Sprue 1

Celiac Sprue, Susceptibility To, 1

Gluten-Sensitive Enteropathy 1

Gluten-Sensitive Enteropathy, Susceptibility To, 1

Idiopathic Steatorrhea

Cœliac Disease

Gluten Intolerance

Gluten-Induced Enteropathy

Gluten Enteropathy

Celiac Disease, Susceptibility To, Type 1

Childhood Celiac Disease

Coeliac Rickets

Gee Disease

Gee-Herter Disease

Heubner-Herter Disease

Idiopathic Steatorrhoea

Thaysen'S Disease

Herter Gee Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06711 IL18RAP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta IL18RAP VGNC VGNC:73715
Felis catus IL18RAP VGNC VGNC:80121
Rattus norvegicus IL18RAP RGD RGD:727867
Bos taurus IL18RAP VGNC VGNC:30128
Canis familiaris IL18RAP VGNC VGNC:41954
Mus musculus IL18RAP MGD MGI:1338888
Others IL18RAP NCBI
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