2. Gene
  3. IL1RL2 - interleukin 1 receptor like 2 Gene

IL1RL2 - interleukin 1 receptor like 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：白介素 1 受体样 2

种属: Homo sapiens

同用名: IL-36R; IL1RRP2; IL-1Rrp2; IL1R-rp2

基因 ID: 8808 | 基因类型: protein coding

关于 IL1RL2

Cytogenetic location: 2q12.1 Genomic coordinates (GRCh38): 2:102,186,973-102,243,086 (from NCBI)

This gene has 4 transcripts (splice variants), 101 orthologues and 10 paralogues. Biased expression in skin (RPKM 3.4), esophagus (RPKM 1.6) and 11 other tissues.

功能概要

由该基因编码的蛋白质是白介素 1 受体家族的成员。瞬时基因表达实验表明，该受体无法以高亲和力与白细胞介素 1 α 和白细胞介素 1 β 结合。该基因和其他四种白细胞介素 1 受体家族基因，包括白细胞介素 1 受体 I 型 (IL1R1) 、白细胞介素 1 受体 II 型 (IL1R2) 、白细胞介素 1 受体样 1 (IL1RL1) 和白细胞介素 18 受体 1 (IL18R1) , 在映射到染色体 2q12 的区域中形成细胞因子受体基因簇。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four Other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008]

IL1RL2 基因产物(6)

mRNA Protein Name
NM_001351446.2 NP_001338375.1 interleukin-1 receptor-like 2 isoform a precursor
NM_001351447.1 NP_001338376.1 interleukin-1 receptor-like 2 isoform b
NM_001351448.1 NP_001338377.1 interleukin-1 receptor-like 2 isoform c
NM_001351449.2 NP_001338378.1 interleukin-1 receptor-like 2 isoform d
NM_001351450.2 NP_001338379.1 interleukin-1 receptor-like 2 isoform d
NM_003854.4 NP_003845.2 interleukin-1 receptor-like 2 isoform a precursor

IL1RL2 蛋白结构

Ig_2

Ig_2: Immunoglobulin domain (31 - 110)

Ig_2

Ig_2: Immunoglobulin domain (126 - 207)

TIR

TIR: TIR domain (385 - 535)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 575 a.a.
蛋白主名 其他名称

interleukin-1 receptor-like 2

IL-1 receptor-related protein 2

重组 IL1RL2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70603 IL-1RL2 Protein, Human (HEK293, His) Q9HB29 (D20-Y337) ≥95%
HY-P70625 IL-1RL2 Protein, Human (HEK293, Fc) Q9HB29 (D20-Y337) ≥95%
HY-P78145 IL-1RL2 Protein, Human (Biotinylated, HEK293, His-Avi) Q9HB29 (D20-R335) ≥95%
HY-P78462 IL-1RL2 Protein, Human (HEK293, His-Avi) Q9HB29 (D20-R335) ≥95%
HY-P78547 IL-1RL2 Protein, Human (C154S, C262S, HEK293, His) Q9HB29 (D20-Y337, C154S, C262S) ≥95%

关联疾病

疾病名称 别名
Familial Cold Autoinflammatory Syndrome 2

FCAS2

Nlrp12-Associated Hereditary Periodic Fever Syndrome

Familial Cold Autoinflammatory Syndrome Type 2

Familial Cold-Induced Autoinflammatory Syndrome Type 2

Naps12

Familial Cold Autoinflammatory Syndrome 2, Susceptibility To

Autoinflammatory Syndrome, Cold, Familial, Type 2
Pustulosis Of Palm And Sole

Psoriasis

Acropustulosis

Palmoplantar Pustulosis

Pustular Psoriasis Of The Palms And/Or Soles

Pustulosis Of Palms And Soles

Acrodermatitis Continua Of Hallopeau

Generalized Pustular Psoriasis
Impetigo Herpetiformis
Psoriasis 14, Pustular

Generalized Pustular Psoriasis

Gpp

Ditra

Acrodermatitis Continua Of Hallopeau

Palmoplantar Pustulosis

PSORS14

Interleukin 36 Receptor Antagonist Deficiency

Psorp

Pustular Psoriasis 14

Deficiency Of Il-36r Antagonist

Acute Generalised Pustular Psoriasis

Deficiency Of The Interleukin-36 Receptor Antagonist

Generalized Pustular Psoriasis Of Von Zumbusch

Von Zumbusch Psoriasis

Deficiency Of Il-36ra

Psoriasis, Pustular, Generalized

Psoriasis, Pustular, Type 14

Pustulosis Of Palms And Soles

Acute Generalized Pustular Psoriasis

Palmoplantar Pustular Psoriasis

Pustulosis Palmaris Et Plantaris

Ppp - [Palmoplantar Pustulosis]

Pustular Psoriasis Of The Palms And Soles

Pustular Bacterid
Pityriasis Rubra Pilaris

PRP

Devergie'S Disease

Prp - [Pityriasis Rubra Pilaris]
Geographic Tongue

Benign Migratory Glossitis

Glossitis Areata Exfoliativa

Glossitis, Benign Migratory

Pityriasis Linguae

Ectopic Geographic Tongue

Erythema Migrans

Erythema Chronicum Migrans

Benign Migrating Glossitis

Geographical Tongue

Lingua Geographica

Erythema Migrans Of Tongue

Wandering Rash Of Tongue
Atrophic Glossitis

Atrophy Of Tongue Papillae

Glossitis, Hunter'S

Hunter'S Glossitis

Smooth Atrophic Tongue

Hunter Glossitis

Central Papillary Atrophy Of The Tongue
Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, And Acne

Papa Syndrome

Fra

Familial Recurrent Arthritis

Pyogenic Arthritis, Pyoderma Gangrenosum And Acne

PAPAS

Pyogenic Arthritis-Pyoderma Gangrenosum-Acne Syndrome

Pyogenic Arthritis, Pyoderma Gangrenosum, And Severe Cystic Acne

Pyogenic Sterile Arthritis, Pyoderma Gangrenosum And Acne
Neutrophilic Dermatosis, Acute Febrile

Sweet Syndrome

Acute Febrile Neutrophilic Dermatosis

Ss

AFND

Pyrin-Associated Autoinflammatory Disease

PAAND

Gomm-Button Disease

Sweet'S Syndrome

Gomm Button Disease

Sweets Syndrome

Acromelic Frontonasal Dysostosis

Sweet Disease
Periodic Fever, Familial, Autosomal Dominant

Familial Hibernian Fever

Tumor Necrosis Factor Receptor-Associated Periodic Syndrome

Traps

FPF

Tnf Receptor-Associated Periodic Fever Syndrome

Hibernian Fever, Familial

Fhf

Tnf Receptor-Associated Periodic Syndrome

Autosomal Dominant Familial Periodic Fever

Periodic Fever, Familial

Tnf Receptor 1-Associated Periodic Syndrome

Tumor Necrosis Factor Receptor 1 Associated Periodic Syndrome

Familial Periodic Fever

Traps Syndrome

Tnf Receptor Associated Periodic Syndrome

Caledonian Fever

Fever, Periodic, Familial

Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome
Periostitis
Mevalonic Aciduria

Mevalonate Kinase Deficiency

Mevalonicaciduria

Hyperimmunoglobulin D With Periodic Fever

MEVA

Complete Mevalonate Kinase Deficiency

Mva

Hyperimmunoglobulinemia D

Hyper Igd Syndrome

Periodic Fever, Dutch Type

Mkd

Aciduria, Mevalonic

Deficiency Of Mevalonate Kinase
Acrodermatitis
Psoriasis 11

PSORS11

Psoriasis Susceptibility 11

Psoriasis

Psoriasis Vulgaris

Psoriasis 11, Susceptibility To

Pv
Impetigo
Autoimmune Disease Of Skin And Connective Tissue
Good Syndrome

Immunodeficiency With Thymoma

Thymoma-Immunodeficiency Syndrome

Thymoma With Hypogammaglobulinemia

Thymoma Immunodeficiency
Diamond-Blackfan Anemia 1

Aase Syndrome

DBA1

Erythrogenesis Imperfecta

Aase-Smith Syndrome Ii

Dba

Blackfan-Diamond Syndrome

Bds

Anemia, Congenital Hypoplastic, Of Blackfan And Diamond

Anemia, Congenital Erythroid Hypoplastic

Red Cell Aplasia, Pure, Hereditary

Aregenerative Anemia, Chronic Congenital

Rps19-Related Diamond-Blackfan Anemia

Chronic Congenital Aregenerative Anemia

Congenital Erythroid Hypoplastic Anemia

Congenital Hypoplastic Anemia Of Blackfan And Diamond

Pure Hereditary Red Cell Aplasia

Anemia, Diamond-Blackfan, Type 1

Anemia, Diamond-Blackfan

Aase Smith Syndrome 2

Familial Hypoplastic Anaemia With Malformations

Constitutional Pure Red Cell Aplasia
Behcet Syndrome

Behcet Disease

Behcet'S Syndrome

Behcet'S Disease

Behçet Disease

Bd

Adamantiades-Behcet Disease

Triple Symptom Complex

Behçet'S Disease

Behet'S Syndrome

Bd Syndrome

Behçet Syndrome

Behçet'S Syndrome

Behcet Triple Symptom Complex

Malignant Aphthosis

Old Silk Route Disease

Adamantiades-Behçet Disease
Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06726 IL1RL2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P991019 Recibokibart Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus IL1RL2 VGNC VGNC:30135
Canis familiaris IL1RL2 VGNC VGNC:108207
Macaca mulatta IL1RL2 VGNC VGNC:73722
Felis catus IL1RL2 VGNC VGNC:67769
Mus musculus IL1RL2 MGD MGI:1913107
Rattus norvegicus IL1RL2 RGD RGD:621782
Macaca fascicularis IL1RL2 NCBI NCBI:102145305
Others IL1RL2 NCBI
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