1. 重组蛋白
  2. Cytokines and Growth Factors Biotinylated Proteins
  3. Interleukin & Receptors
  4. IL-1 Rrp2
  5. IL-1RL2 蛋白, Human (Biotinylated, HEK293, His-Avi)

IL-1RL2 蛋白, Human (Biotinylated, HEK293, His-Avi)

目录号: HY-P78145
产品使用指南

IL-1RL2 蛋白作为白细胞介素 36(IL36A、IL36B 和 IL36G)的受体,与辅助受体 IL1RAP 形成复合物,构成白细胞介素 36 受体。该复合物可激活 NF-kappa-B、MAPK 和其他途径,类似于 IL-1 系统。IL-1RL2 参与上皮屏障的局部炎症反应,特别是通过诱导 IL-23/IL-17/IL-22 途径促进皮肤炎症反应。IL-1RL2 蛋白, Human (Biotinylated, HEK293, His-Avi) 是重组的 IL-1RL2 蛋白,由 HEK293 表达,带有 C-Avi, C-His 标签。IL-1RL2 蛋白, Human (Biotinylated, HEK293, His-Avi) 全长 316 个氨基酸,分子量为 55-75 kDa。

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描述

IL-1RL2 Protein, serving as a receptor for interleukin-36 (IL36A, IL36B, and IL36G), forms a complex with the coreceptor IL1RAP, constituting the interleukin-36 receptor. This complex activates NF-kappa-B, MAPK, and other pathways, resembling the IL-1 system. IL-1RL2 is implicated in local inflammatory responses at epithelial barriers, particularly contributing to skin inflammatory reactions by inducing the IL-23/IL-17/IL-22 pathway. IL-1RL2 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived IL-1RL2 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of IL-1RL2 Protein, Human (Biotinylated, HEK293, His-Avi) is 316 a.a., with molecular weight of 55-75 kDa.

研究背景

IL-1RL2 是白细胞介素 36(IL36A、IL36B 和 IL36G)的受体,在与白细胞介素 36 结合后参与复杂的信号转导事件。通过与辅助受体 IL1RAP 结合,形成白细胞介素 36 受体复合物,协调白细胞介素 36 依赖性的 NF-κ-B、MAPK 和其他途径的激活。该信号系统类似于 IL-1 系统,与上皮屏障内的局部炎症反应有关,特别是通过诱导 IL-23/IL-17/IL-22 途径促进皮肤炎症反应。

种属

Human

表达系统

HEK293

标签

C-Avi;C-His

蛋白编号

Q9HB29 (D20-R335)

基因 ID
蛋白结构
N-term
IL-1RL2 (D20-R335)
Accession # Q9HB29
His-Avi
C-term
同用名
IL-1 R6; IL-1 Rrp2; IL1RL2; IL1Rrp2; IL1RRP2; IL-36R
分子量

55-75 kDa

纯度

Greater than 95% as determined by Tris-Bis PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

IL-1RL2 Protein, Human (Biotinylated, HEK293, His-Avi) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
IL-1RL2 Protein, Human (Biotinylated, HEK293, His-Avi)
目录号:
HY-P78145
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