2. Gene
  3. GGH - gamma-glutamyl hydrolase Gene

GGH - gamma-glutamyl hydrolase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：γ-谷氨酰水解酶

种属: Homo sapiens

同用名: GH; GATD10

基因 ID: 8836 | 基因类型: protein coding

关于 GGH

Cytogenetic location: 8q12.3 Genomic coordinates (GRCh38): 8:63,015,079-63,038,806 (from NCBI)

This gene has 15 transcripts (splice variants) and 209 orthologues. Broad expression in kidney (RPKM 36.6), liver (RPKM 31.0) and 19 other tissues.

功能概要

该基因通过去除γ连接的聚谷氨酸和谷氨酸来催化叶酰聚-γ-谷氨酸和抗叶酰聚-γ-谷氨酸的水解。[RefSeq 提供，2008 年 7 月]

This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq, Jul 2008]

GGH 基因产物(2)

mRNA Protein Name
NM_001410926.1 NP_001397855.1 gamma-glutamyl hydrolase isoform 2 precursor
NM_003878.3 NP_003869.1 gamma-glutamyl hydrolase isoform 1 precursor
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables gamma-glutamyl-peptidase activity IDA
IDA: 通过直接分析推断
11005824 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
25645918 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GGH 蛋白结构

Peptidase_C26

Peptidase_C26: Peptidase C26 (34 - 246)

  • 0
  • 100
  • 200
  • 300
  • 318 a.a.
蛋白主名 其他名称

gamma-glutamyl hydrolase

gamma-Glu-X carboxypeptidase

GGH 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GGH Q92820 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
种属内
GGH Q92820 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
种属内
GGH Q92820 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 GGH 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76953 GGH/Glutamyl hydrolase gamma Protein, Human (HEK293, His) Q92820/NP_003869.1(M25-D318) ≥95%

关联疾病

疾病名称 别名
Tropical Sprue

Tropical Steatorrhea

Tropical Enteropathy

Sprue, Tropical

Sprue - Tropical

Idiopathic Tropical Malabsorption Syndrome

Tropical Steatorrhoea

Tropical Diarrhoea

Ts - [Tropical Sprue]

Psilosis

Sprue Nos
Pulmonary Neuroendocrine Tumor

Neuroendocrine Neoplasm Of Lung
Folate Malabsorption, Hereditary

Hereditary Folate Malabsorption

Congenital Defect Of Folate Absorption

Congenital Folate Malabsorption

Folic Acid Transport Defect

HFM
Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05399 GGH Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris GGH VGNC VGNC:41198
Mus musculus GGH MGD MGI:1329035
Felis catus GGH VGNC VGNC:62537
Macaca mulatta GGH VGNC VGNC:104457
Bos taurus GGH VGNC VGNC:29340
Rattus norvegicus GGH RGD RGD:2682
Others GGH NCBI
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