2. Gene
  3. KCNK17 - potassium two pore domain channel subfamily K member 17 Gene

KCNK17 - potassium two pore domain channel subfamily K member 17 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品

中文名称：钾二孔域通道亚科 K 成员 17

种属: Homo sapiens

同用名: TALK2; TASK4; TALK-2; TASK-4; K2p17.1

基因 ID: 89822 | 基因类型: protein coding

关于 KCNK17

Cytogenetic location: 6p21.2 Genomic coordinates (GRCh38): 6:39,299,001-39,314,419 (from NCBI)

This gene has 3 transcripts (splice variants), 225 orthologues and 14 paralogues. Broad expression in lung (RPKM 2.2), stomach (RPKM 1.6) and 18 other tissues.

功能概要

由该基因编码的蛋白质属于含有两个成孔 P 结构域的钾通道蛋白家族。该通道是一个开放式整流器，主要在生理 K+ 浓度下传递外向电流。该基因在碱性 pH 值下被激活。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2008 年 9 月]

The protein encoded by this gene belongs to the family of Potassium Channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

KCNK17 基因产物(2)

mRNA Protein Name
NM_001135111.2 NP_001128583.1 potassium channel subfamily K member 17 isoform 2
NM_031460.4 NP_113648.2 potassium channel subfamily K member 17 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables outward rectifier potassium channel activity IDA
IDA: 通过直接分析推断
26919430 GOA
enables potassium channel activity IDA
IDA: 通过直接分析推断
11248242 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in potassium ion transport IDA
IDA: 通过直接分析推断
11248242 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KCNK17 蛋白结构

Ion_trans_2

Ion_trans_2: Ion channel (93 - 156)

Ion_trans_2

Ion_trans_2: Ion channel (190 - 267)

  • 0
  • 100
  • 200
  • 300
  • 332 a.a.
蛋白主名 其他名称

potassium channel subfamily K member 17

2P domain potassium channel Talk-2

关联疾病

疾病名称 别名
Birk-Barel Syndrome

Birk-Barel Mental Retardation Dysmorphism Syndrome

BIBARS

Mental Retardation With Hypotonia And Facial Dysmorphism

Intellectual Disability-Hypotonia-Facial Dysmorphism Syndrome

Kcnk9 Imprinting Syndrome
Long Qt Syndrome

Romano-Ward Syndrome

Long Q-T Syndrome

Lqt

Qt Syndrome, Long

Congenital Long Qt Syndrome

Familial Long Qt Syndrome
Brain Small Vessel Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07156 KCNK17 Human Pre-designed siRNA Set A Pre-designed Sets / 否
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