2. Gene
  3. FGD3 - FYVE, RhoGEF and PH domain containing 3 Gene

FGD3 - FYVE, RhoGEF and PH domain containing 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 FYVE、RhoGEF 和 PH 域 3

种属: Homo sapiens

同用名: ZFYVE5

基因 ID: 89846 | 基因类型: protein coding

关于 FGD3

Cytogenetic location: 9q22.31 Genomic coordinates (GRCh38): 9:92,947,523-93,036,233 (from NCBI)

This gene has 8 transcripts (splice variants), 189 orthologues and 10 paralogues. Broad expression in spleen (RPKM 16.0), lymph node (RPKM 14.2) and 17 other tissues.

功能概要

预测可实现胍基核苷酸交换因子活性和小 GTP 酶结合活性。预计将参与多个过程，包括丝状足的组装；调节 GTPase 活性；和细胞形状的调节。预测位于高尔基体；片状足；和荷叶边。预计在细胞质中有活性。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in several processes, including filopodium assembly; regulation of GTPase activity; and regulation of cell shape. Predicted to be located in Golgi apparatus; lamellipodium; and ruffle. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

FGD3 基因产物(5)

mRNA Protein Name
NM_001083536.2 NP_001077005.1 FYVE, RhoGEF and PH domain-containing protein 3 isoform a
NM_001286993.2 NP_001273922.1 FYVE, RhoGEF and PH domain-containing protein 3 isoform b
NM_001369951.1 NP_001356880.1 FYVE, RhoGEF and PH domain-containing protein 3 isoform a
NM_001369952.1 NP_001356881.1 FYVE, RhoGEF and PH domain-containing protein 3 isoform c
NM_033086.3 NP_149077.2 FYVE, RhoGEF and PH domain-containing protein 3 isoform a

FGD3 蛋白结构

RhoGEF

RhoGEF: RhoGEF domain (161 - 339)

PH

PH: PH domain (371 - 468)

FYVE

FYVE: FYVE zinc finger (530 - 584)

  • 0
  • 200
  • 400
  • 600
  • 725 a.a.
蛋白主名 其他名称

FYVE, RhoGEF and PH domain-containing protein 3

FGD1 family, member 3

关联疾病

疾病名称 别名
Aarskog-Scott Syndrome

Aarskog Syndrome

Faciogenital Dysplasia

Faciodigitogenital Syndrome

AAS

Fgdy

X-Linked Aarskog Syndrome

Intellectual Developmental Disorder, X-Linked, Syndromic 16

Aarskog Syndrome, X-Linked

Intellectual Developmental Disorder, X-Linked Syndromic 16

Greig'S Syndrome

Aarskog Scott Syndrome

Aarskog Disease

Scott Aarskog Syndrome

Facio-Digito-Genital Dysplasia

Faciogenital Dysplasia With Attention Deficit-Hyperactivity Disorder

Aarskog-Scott Syndrome ) Syndrome
Familial Glucocorticoid Deficiency

Glucocorticoid Deficiency

Acth Resistance

Adrenal Unresponsiveness To Acth

Hereditary Unresponsiveness To Adrenocorticotropic Hormone

Isolated Glucocorticoid Deficiency

Glucocorticoid Deficiency, Familial

Glucocorticoid Deficiency 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04882 FGD3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus FGD3 VGNC VGNC:62241
Macaca mulatta FGD3 VGNC VGNC:72512
Rattus norvegicus FGD3 RGD RGD:1311725
Bos taurus FGD3 VGNC VGNC:28966
Canis familiaris FGD3 VGNC VGNC:40835
Mus musculus FGD3 MGD MGI:1353657
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