2. Gene
  3. SLC25A21 - solute carrier family 25 member 21 Gene

SLC25A21 - solute carrier family 25 member 21 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 25 成员 21

种属: Homo sapiens

同用名: ODC; ODC1; MTDPS18

基因 ID: 89874 | 基因类型: protein coding

关于 SLC25A21

Cytogenetic location: 14q13.3 Genomic coordinates (GRCh38): 14:36,677,921-37,172,606 (from NCBI)

This gene has 5 transcripts (splice variants), 203 orthologues, 49 paralogues and is associated with 1 phenotype. Biased expression in esophagus (RPKM 5.4), salivary gland (RPKM 2.6) and 13 other tissues.

功能概要

SLC25A21 是酿酒酵母 ODC 蛋白的同源物，是将 C5-C7 氧代二羧酸盐转运穿过线粒体内膜的线粒体载体。 ODC 转运的物质之一是 2-氧代己二酸，它是哺乳动物赖氨酸、色氨酸和羟赖氨酸分解代谢中的常见中间体。在线粒体内，2-氧代己二酸转化为乙酰辅酶 A。[OMIM 提供，2004 年 4 月]

SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.[supplied by OMIM, Apr 2004]

SLC25A21 基因产物(2)

mRNA Protein Name
NM_001171170.2 NP_001164641.1 mitochondrial 2-oxodicarboxylate carrier isoform 2
NM_030631.4 NP_085134.1 mitochondrial 2-oxodicarboxylate carrier isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables alpha-ketoglutarate transmembrane transporter activity IDA
IDA: 通过直接分析推断
11083877 GOA
enables alpha-ketoglutarate transmembrane transporter activity IMP
IMP: 通过突变表型推断
29517768 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mitochondrial alpha-ketoglutarate transmembrane transport IMP
IMP: 通过突变表型推断
29517768 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC25A21 蛋白结构

Mito_carr

Mito_carr: Mitochondrial carrier protein (14 - 101)

Mito_carr

Mito_carr: Mitochondrial carrier protein (110 - 198)

Mito_carr

Mito_carr: Mitochondrial carrier protein (206 - 297)

  • 0
  • 100
  • 200
  • 299 a.a.
蛋白主名 其他名称

mitochondrial 2-oxodicarboxylate carrier

mitochondrial 2-oxoadipate carrier

关联疾病

疾病名称 别名
Mitochondrial Dna Depletion Syndrome 18

MTDPS18
Mitochondrial Dna Depletion Syndrome

Mtdna Depletion Syndrome
Alpha-Aminoadipic And Alpha-Ketoadipic Aciduria

2-Aminoadipic 2-Oxoadipic Aciduria

Amoxad

AAKAD

2-Ketoadipic Aciduria

Alpha-Aminoadipic Aciduria

Amino Adipic Aciduria

Aciduria, 2-Aminoadipic 2-Oxoadipic
Combined D-2- And L-2-Hydroxyglutaric Aciduria

D,L-2-Hydroxyglutaric Aciduria

D2L2AD

Combined D-2-Hydroxyglutaric Acidemia And L-2-Hydroxyglutaric Acidemia

Combined D-2-Hydroxyglutaric Aciduria And L-2-Hydroxyglutaric Aciduria

D,L-2-Hga

D,L-2-Hydroxyglutaric Acidemia

Combined D,L-2-Hydroxyglutaric Aciduria
Synpolydactyly

Syndactyly Type 2

Syndactyly, Type 2

Spd
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13102 SLC25A21 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus SLC25A21 VGNC VGNC:65263
Canis familiaris SLC25A21 VGNC VGNC:46300
Mus musculus SLC25A21 MGD MGI:2445059
Macaca mulatta SLC25A21 VGNC VGNC:77475
Bos taurus SLC25A21 VGNC VGNC:34749
Rattus norvegicus SLC25A21 RGD RGD:621444
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