2. Gene
  3. F2RL3 - F2R like thrombin or trypsin receptor 3 Gene

F2RL3 - F2R like thrombin or trypsin receptor 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：F2R 样凝血酶或胰蛋白酶受体 3

种属: Homo sapiens

同用名: PAR4

基因 ID: 9002 | 基因类型: protein coding

关于 F2RL3

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:16,888,999-16,892,606 (from NCBI)

This gene has 2 transcripts (splice variants), 194 orthologues and 16 paralogues. Broad expression in fat (RPKM 1.9), stomach (RPKM 1.3) and 16 other tissues.

功能概要

该基因编码蛋白酶激活受体亚家族的成员，是 G 蛋白偶联受体 1 蛋白家族的一部分。编码的受体经过蛋白水解处理，以揭示结合并激活受体的细胞外 N 末端栓系配体。这种受体在血液凝固、炎症和对疼痛的反应中发挥作用。该基因的低甲基化可能与人类患者的肺癌有关。[RefSeq 提供，2016 年 9 月]

This gene encodes a member of the Protease-activated Receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Hypomethylation at this gene may be associated with lung Cancer in human patients. [provided by RefSeq, Sep 2016]

F2RL3 基因产物(1)

mRNA Protein Name
NM_003950.4 NP_003941.2 proteinase-activated receptor 4 preproprotein
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protease binding IPI
IPI: 通过物理相互作用推断
18434511 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in platelet activation IDA
IDA: 通过直接分析推断
10702240 GOA
involved in positive regulation of release of sequestered calcium ion into cytosol IDA
IDA: 通过直接分析推断
18480058 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

F2RL3 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (95 - 340)

  • 0
  • 100
  • 200
  • 300
  • 385 a.a.
蛋白主名 其他名称

proteinase-activated receptor 4

F2R like thrombin/trypsin receptor 3

PAR-4

coagulation factor II (thrombin) receptor-like 3

protease-activated receptor-4

thrombin receptor-like 3

关联疾病

疾病名称 别名
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04640 F2RL3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04641 F2rl3 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04642 F2rl3 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus F2RL3 VGNC VGNC:28686
Mus musculus F2RL3 MGD MGI:1298207
Canis familiaris F2RL3 VGNC VGNC:40550
Felis catus F2RL3 VGNC VGNC:62025
Rattus norvegicus F2RL3 RGD RGD:620872
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