CCNG2 - cyclin G2 Gene

中文名称：细胞周期素 G2

种属: Homo sapiens

关于 CCNG2

功能概要

真核细胞周期由细胞周期蛋白依赖性蛋白激酶 (CDK) 控制，其活性受细胞周期蛋白和 CDK 抑制剂调节。哺乳动物中报道的 8 种细胞周期蛋白，细胞周期蛋白 A 到 H，共享一个约 90 个残基的保守氨基酸序列，称为细胞周期蛋白盒。细胞周期蛋白 G 的氨基酸序列在哺乳动物中非常保守。细胞周期蛋白 G1 和细胞周期蛋白 G2 的核苷酸序列有 53% 相同。与细胞周期蛋白 G1 不同，细胞周期蛋白 G2 包含 C 末端 PEST 蛋白去稳定化基序，表明细胞周期蛋白 G2 的表达在细胞周期中受到严格调控。[RefSeq 提供，2008 年 7 月]

The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle. [provided by RefSeq, Jul 2008]