1. Gene
  2. ESAM - endothelial cell adhesion molecule Gene

ESAM - endothelial cell adhesion molecule Gene

中文名称:内皮细胞粘附分子

种属: Homo sapiens

同用名: W117m

基因 ID: 90952 | 基因类型: protein coding

关于 ESAM

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:124,753,126-124,762,290 (from NCBI)

This gene has 6 transcripts (splice variants), 292 orthologues and 14 paralogues. Broad expression in placenta (RPKM 71.1), thyroid (RPKM 67.5) and 21 other tissues.

功能概要

启用细胞间粘附介质活性。参与多个过程,包括双细胞紧密连接组装;细胞间粘附;和肌动蛋白细胞骨架组织的调节。位于细胞间连接处和质膜上。部分含蛋白质复合物。 [由基因组资源联盟提供,2022 年 4 月]

Enables cell-cell adhesion mediator activity. Involved in several processes, including bicellular tight junction assembly; cell-cell adhesion; and regulation of actin Cytoskeleton organization. Located in cell-cell junction and plasma membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

ESAM 基因产物(1)

mRNA Protein Name
NM_138961.3 NP_620411.2 endothelial cell-selective adhesion molecule precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cell-cell adhesion mediator activity IDA
IDA: 通过直接分析推断
20298433 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
26607202 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in bicellular tight junction assembly IMP
IMP: 通过突变表型推断
26607202 GOA
involved in cell-cell adhesion IDA
IDA: 通过直接分析推断
20298433 GOA
involved in protein localization IDA
IDA: 通过直接分析推断
20298433 GOA
involved in regulation of actin cytoskeleton organization IDA
IDA: 通过直接分析推断
20298433 GOA
involved in regulation of actin filament polymerization IDA
IDA: 通过直接分析推断
20298433 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell-cell junction IDA
IDA: 通过直接分析推断
20298433 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
20298433 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
26607202 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ESAM 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (36 - 139)

Ig_2

Ig_2: Immunoglobulin domain (163 - 240)

  • 0
  • 100
  • 200
  • 300
  • 390 a.a.
蛋白主名 其他名称

endothelial cell-selective adhesion molecule

2310008D05Rik

重组 ESAM 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70889 ESAM Protein, Human (HEK293, His) Q96AP7-1 (Q30-A247 ) ≥95%

关联疾病

疾病名称 别名
Aqueous Misdirection
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ESAM VGNC VGNC:53356
Macaca mulatta ESAM VGNC VGNC:72290
Rattus norvegicus ESAM RGD RGD:1303286
Felis catus ESAM VGNC VGNC:102878
Mus musculus ESAM MGD MGI:1916774
Bos taurus ESAM VGNC VGNC:50042
Others ESAM NCBI