AIMP1 - aminoacyl tRNA synthetase complex interacting multifunctional protein 1 Gene

中文名称：氨酰 tRNA 合成酶复合物相互作用多功能蛋白 1

种属: Homo sapiens

同用名: p43; HLD3; EMAP2; SCYE1; EMAPII

基因 ID: 9255 | 基因类型: protein coding

关于 AIMP1

Cytogenetic location: 4q24 Genomic coordinates (GRCh38): 4:106,315,544-106,349,456 (from NCBI)

This gene has 19 transcripts (splice variants), 306 orthologues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 9.6), prostate (RPKM 7.6) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种由细胞凋亡特异性诱导的细胞因子，参与血管生成、炎症和伤口愈合的控制。这种细胞因子的释放使肿瘤相关脉管系统对肿瘤坏死因子敏感。前体蛋白与 p43 亚基相同，后者与多 tRNA 合成酶复合物相关，可调节正常细胞中 tRNA 合成酶的氨酰化活性。该蛋白还参与肿瘤细胞蛋白水解切割后炎症反应的刺激。已发现该基因编码不同异构体的多个转录变体。已在 20 号染色体上鉴定出假基因。[RefSeq 提供，2008 年 12 月]

The protein encoded by this gene is a cytokine that is specifically induced by Apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008]

AIMP1 基因产物(3)

mRNA	Protein	Name
NM_001142415.2	NP_001135887.1	aminoacyl tRNA synthase complex-interacting multifunctional protein 1 precursor
NM_001142416.2	NP_001135888.2	aminoacyl tRNA synthase complex-interacting multifunctional protein 1 precursor
NM_004757.4	NP_004748.2	aminoacyl tRNA synthase complex-interacting multifunctional protein 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables GTPase binding	IPI IPI: 通过物理相互作用推断	24337748	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11741979	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	11306575	GOA
enables tRNA binding	IDA IDA: 通过直接分析推断	11306575	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cell-cell signaling	IDA IDA: 通过直接分析推断	11741979	GOA
involved in leukocyte migration	IDA IDA: 通过直接分析推断	11306575	GOA
involved in negative regulation of endothelial cell proliferation	IDA IDA: 通过直接分析推断	11741979	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of aminoacyl-tRNA synthetase multienzyme complex	IDA IDA: 通过直接分析推断	10791971	GOA
located in cell surface	IDA IDA: 通过直接分析推断	11741979	GOA
located in cytosol	IDA IDA: 通过直接分析推断	19289464	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AIMP1 蛋白结构

tRNA_bind

0
100
200
312 a.a.

蛋白主名

其他名称

aminoacyl tRNA synthase complex-interacting multifunctional protein 1

ARS-interacting multifunctional protein 1

AIMP1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	AIMP1	Q12904	TSNAX	Homo sapiens	Q99598	Validated Y2H	25416956
种属内	AIMP1	Q12904	AIMP2	Homo sapiens	Q13155	Anti Tag CoIP	33961781
种属内	AIMP1	Q12904	AIMP2	Homo sapiens	Q13155	Anti Tag CoIP	28514442
种属内	AIMP1	Q12904	AIMP2	Homo sapiens	Q13155	Y2H Array	25416956
种属间	AIMP1	Q12904	P04591-PRO_0000038593	Human immunodeficiency virus	P04591-PRO_0000038593	Pull Down	22190034

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 AIMP1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7156	EMAP-II Protein, Human	Q12904 (S147-K312)	≥95%

AIMP1 抗体

目录号	产品名	应用	反应物种
HY-P83018	EMAP II Antibody (YA2763)	WB	Human, Rat

关联疾病

疾病名称

别名

Leukodystrophy, Hypomyelinating, 3

Hypomyelinating Leukodystrophy 3	HLD3
Pelizaeus-Merzbacher-Like Disease Due To Aimp1 Mutation	Leukodystrophy, Hypomyelinating 3
Perinatal Sudanophilic Leukodystrophy	Leukodystrophy, Hypomyelinating, Type 3
Pelizaeus-Merzbacher-Like Disease, Autosomal Recessive, 2

Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid

Hypotonia

Hypomyelinating Leukodystrophy

Hld	Leukodystrophy, Hypomyelinating

Fibrosarcoma

Neoplasms, Fibrous Tissue	Fibrocytic Tumor
Fibrosarcoma Of Soft Tissue	Fibrous Tissue Neoplasm

Leukodystrophy, Hypomyelinating, 7, With Or Without Oligodontia And/Or Hypogonadotropic Hypogonadism

HLD7	Leukoencephalopathy-Ataxia-Hypodontia-Hypomyelination Syndrome
Addh	Leukodystrophy, Hypomyelinating, With Hypodontia And Hypogonadotropic Hypogonadism
4h Syndrome	4h Leukodystrophy 1
Hypomyelinating Leukodystrophy 7 With Or Without Oligodontia And-Or Hypogonadotropic Hypogonadism	Hypomyelination-Cerebellar Atrophy-Hypoplasia Of The Corpus Callosum Syndrome
Leukodystrophy With Oligodontia	Tach Syndrome
Tremor-Ataxia-Central Hypomyelination Syndrome	Leukoencephalopathy, Hypomyelinating, With Ataxia And Delayed Dentition
Ataxia, Delayed Dentition, And Hypomyelination	Ataxia-Delayed Dentition-Hypomyelination Syndrome
Odontoleukodystrophy	Dentoleukoencephalopathy
Hypomyelinating Leukodystrophy-Ataxia-Hypodontia-Hypomyelination Syndrome	Ataxia-Delayed Dentition-Hypomyelination Syndrome
Ataxia Delayed Dentition And Hypomyelination	Leukodystrophy Hypomyelinating With Hypodontia And Hypogonadotropic Hypogonadism 4h Syndrome
Leukoencephalopathy Hypomyelinating With Ataxia And Delayed Dentition	Tach
Tremor-Ataxia With Central Hypomyelination	Attention Deficit Hyperactivity Disorder
Leukodystrophy, Dysmyelinating, With Oligodontia

Leukodystrophy, Hypomyelinating, 9

Hypomyelinating Leukodystrophy 9	HLD9
Rars-Related Autosomal Recessive Hypomyelinating Leukodystrophy	Leukodystrophy, Hypomyelinating, Type 9

Leukodystrophy

Leukodystrophies

Charcot-Marie-Tooth Disease, Dominant Intermediate C

CMTDIC	Charcot-Marie-Tooth Disease Dominant Intermediate C
Di-Cmtc	Autosomal Dominant Intermediate Charcot-Marie-Tooth Disease Type C
Charcot-Marie-Tooth Neuropathy, Dominant Intermediate C	Charcot-Marie-Tooth Neuropathy Dominant Intermediate C
Charcot-Marie-Tooth Disease, Dominant, Intermediate Type, C	Charcot-Marie-Tooth Disease, Dominant Intermediate, Type C

Pelizaeus-Merzbacher Disease

PMD	HLD1
Pelizaeus-Merzbacher Brain Sclerosis	Leukodystrophy, Hypomyelinating, 1
Diffuse Familial Brain Sclerosis	Pelizaeus Merzbacher Brain Sclerosis
Sudanophilic Leukodystrophy, Paelizeus-Merzbacher Type	Cockayne-Pelizaeus-Merzbacher Disease
Hypomyelinating Leukodystrophy 1	Leukodystrophy, Sudanophilic
Pelizaeus Merzbacher Disease	Hypomyelinating Leukodystrophy, 1
Sudanophilic Leukodystrophy	Pelizaeus-Merzbacher Disease, Connatal Form
Connatal Pmd	Pelizaeus-Merzbacher Disease Type Ii
Severe Pmd	Null Syndrome
Plp1 Null Syndrome	Pelizaeus-Merzbacher Disease, Null Syndrome
Brain Sclerosis Diffuse Familial	Sudanophilic Leukodystrophy Paelizeus-Merzbacher Type
Leukodystrophy Hypomyelinating 1	Diffuse Cerebral Sclerosis Of Schilder

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Alcohol Dependence, Protection Against	Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00497	AIMP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	AIMP1	VGNC	VGNC:25765
Rattus norvegicus	AIMP1	RGD	RGD:620466
Felis catus	AIMP1	VGNC	VGNC:78451
Canis familiaris	AIMP1	VGNC	VGNC:103659
Macaca mulatta	AIMP1	VGNC	VGNC:69599
Mus musculus	AIMP1	MGD	MGI:102774
Others	AIMP1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

AIMP1 - aminoacyl tRNA synthetase complex interacting multifunctional protein 1 Gene

关于 AIMP1

功能概要

AIMP1 基因产物(3)

AIMP1 蛋白结构

AIMP1 蛋白互作信息

重组 AIMP1 蛋白

AIMP1 抗体

关联疾病

直系同源

热门区域

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AIMP1 - aminoacyl tRNA synthetase complex interacting multifunctional protein 1 Gene

关于 AIMP1

功能概要

AIMP1 基因产物(3)

AIMP1 蛋白结构

AIMP1 蛋白互作信息

重组 AIMP1 蛋白

AIMP1 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z