1. Gene
  2. CPA5 - carboxypeptidase A5 Gene

CPA5 - carboxypeptidase A5 Gene

中文名称:羧肽酶 A5

种属: Homo sapiens

基因 ID: 93979 | 基因类型: protein coding

关于 CPA5

Cytogenetic location: 7q32.2 Genomic coordinates (GRCh38): 7:130,344,816-130,374,599 (from NCBI)

This gene has 11 transcripts (splice variants), 145 orthologues and 8 paralogues. Restricted expression toward testis (RPKM 7.8).

功能概要

羧肽酶的功能范围从食物的消化到神经内分泌肽的选择性生物合成。羧肽酶 A/B 亚家族的成员,如 CPA5,包含一个大约 90 个氨基酸的前区,有助于活性羧肽酶结构域的折叠。 pro 区域的切割激活酶 (Wei 等人,2002 [PubMed 11836249]) 。[OMIM 提供,2008 年 3 月]

Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine Peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro region that assists in the folding of the active Carboxypeptidase domain. Cleavage of the pro region activates the Enzyme (Wei et al., 2002 [PubMed 11836249]).[supplied by OMIM, Mar 2008]

CPA5 基因产物(4)

mRNA Protein Name
NM_001127441.2 NP_001120913.1 carboxypeptidase A5 isoform 1 precursor
NM_001127442.2 NP_001120914.1 carboxypeptidase A5 isoform 2 precursor
NM_001318223.2 NP_001305152.1 carboxypeptidase A5 isoform 1 precursor
NM_080385.5 NP_525124.3 carboxypeptidase A5 isoform 1 precursor

CPA5 蛋白结构

Propep_M14

Propep_M14: Carboxypeptidase activation peptide (43 - 118)

Peptidase_M14

Peptidase_M14: Zinc carboxypeptidase (145 - 422)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 436 a.a.
蛋白主名 其他名称

carboxypeptidase A5

testicular tissue protein Li 32

关联疾病

疾病名称 别名
Amebiasis

Amoebiasis

Entamoebiasis

Chronic Intestinal Amebiasis

Amoebiasis, Unspecified

Amebic Colitis

Amoebic Enteritis

Infection Due To Entamoeba Histolytica

Amoebic Infection

Disease Due To Endamoebidae

Amoebiasis Nos

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus CPA5 VGNC VGNC:61115
Bos taurus CPA5 VGNC VGNC:107221
Canis familiaris CPA5 VGNC VGNC:39546
Rattus norvegicus CPA5 RGD RGD:1303098
Mus musculus CPA5 MGD MGI:1921899
Macaca mulatta CPA5 VGNC VGNC:71410