2. Gene
  3. NTN1 - netrin 1 Gene

NTN1 - netrin 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：netrin 1

种属: Homo sapiens

同用名: NET1; MRMV4; NTN1L

基因 ID: 9423 | 基因类型: protein coding

关于 NTN1

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:9,003,087-9,244,000 (from NCBI)

This gene has 2 transcripts (splice variants), 270 orthologues, 27 paralogues and is associated with 2 phenotypes. Broad expression in heart (RPKM 20.8), esophagus (RPKM 16.8) and 17 other tissues.

功能概要

Netrin 属于层粘连蛋白相关分泌蛋白家族。该基因的功能尚未确定；然而，netrin 被认为参与了发育过程中的轴突导向和细胞迁移。 netrin 的突变和表达缺失表明 netrin 的变异可能与癌症的发展有关。[RefSeq 提供，2008 年 7 月]

Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in Cancer development. [provided by RefSeq, Jul 2008]

NTN1 基因产物(1)

mRNA Protein Name
NM_004822.3 NP_004813.2 netrin-1 precursor
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10102268 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular region IDA
IDA: 通过直接分析推断
28945198 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NTN1 蛋白结构

Laminin_N

Laminin_N: Laminin N-terminal (Domain VI) (51 - 283)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (285 - 333)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (341 - 392)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (404 - 445)

NTR

NTR: UNC-6/NTR/C345C module (488 - 594)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 604 a.a.
蛋白主名 其他名称

netrin-1

epididymis tissue protein Li 131P

NTN1 抗体

目录号 产品名 应用 反应物种
HY-P81897 Netrin 1 Antibody (YA1642) WB, ICC/IF Human, Mouse, Rat

关联疾病

疾病名称 别名
Mirror Movements 4

MRMV4
Mirror Movements 1

Congenital Mirror Movement Disorder

Bimanual Synergia

Congenital Mirror Movements

Familial Congenital Controlateral Synkinesia

Familial Congenital Mirror Movements

Hereditary Congenital Controlateral Synkinesia

Hereditary Congenital Mirror Movements

Isolated Congenital Controlateral Synkinesia

Isolated Congenital Mirror Movements

Mirror Movements

MRMV1

Mirror Movements 1 And/Or Agenesis Of The Corpus Callosum

Mirror Movements, Congenital

Bimanual Synkinesis

Cmm

Mirror Movements, Type 1
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Hydronephrosis

Stricture Of Ureteropelvic Junction With Hydronephrosis

Hydronephrosis With Ureteral Stricture, Not Elsewhere Classified
Cleft Palate, Isolated

Cleft Palate

Isolated Cleft Palate

CPI

Cp

Palatoschisis

Cleft Palate Isolated

Uranostaphyloschisis

Congenital Fissure Of Palate

Cleft Of Secondary Palate
Kallmann Syndrome

Hypogonadism With Anosmia

Kallman'S Syndrome

Anosmic Hypogonadism

Anosmic Idiopathic Hypogonadotropic Hypogonadism

Hypogonadotropic Hypogonadism And Anosmia

Hypogonadotropic Hypogonadism-Anosmia Syndrome

Olfacto-Genital Pathological Sequence

Familial Hypogonadism With Anosmia

Kallman Syndrome

Dysplasia Olfactogenitalis Of De Morsier

Kallmann'S Syndrome

Congenital Hypogonadotropic Hypogonadism With Anosmia
Orofacial Cleft

Cleft, Orofacial
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09621 NTN1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus NTN1 VGNC VGNC:99313
Rattus norvegicus NTN1 RGD RGD:619809
Mus musculus NTN1 MGD MGI:105088
Bos taurus NTN1 VGNC VGNC:32304
Canis familiaris NTN1 VGNC VGNC:44007
Macaca mulatta NTN1 VGNC VGNC:104637
Others NTN1 NCBI
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