GGPS1 - geranylgeranyl diphosphate synthase 1 Gene

中文名称：香叶基香叶基二磷酸合酶 1

种属: Homo sapiens

同用名: GGPPS; MDHLO; GGPPS1; MUDHLOV

基因 ID: 9453 | 基因类型: protein coding

关于 GGPS1

Cytogenetic location: 1q42.3 Genomic coordinates (GRCh38): 1:235,327,216-235,344,532 (from NCBI)

This gene has 8 transcripts (splice variants), 203 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 14.2), prostate (RPKM 11.1) and 25 other tissues.

功能概要

该基因是异戊烯基转移酶家族的成员，编码具有香叶基香叶基二磷酸 (GGPP) 合酶活性的蛋白质。该酶催化法尼基二磷酸和异戊烯基二磷酸合成 GGPP。 GGPP 是一种重要的分子，负责蛋白质的 C20-异戊二烯化和核激素受体的调节。已经发现该基因的替代转录剪接变体，包括蛋白质编码和非蛋白质编码。[RefSeq 提供，2010 年 9 月]

This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The Enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]

GGPS1 基因产物(5)

mRNA	Protein	Name
NM_001037277.1	NP_001032354.1	geranylgeranyl pyrophosphate synthase isoform A
NM_001037278.2	NP_001032355.1	geranylgeranyl pyrophosphate synthase isoform B
NM_001371477.1	NP_001358406.1	geranylgeranyl pyrophosphate synthase isoform A
NM_001371478.1	NP_001358407.1	geranylgeranyl pyrophosphate synthase isoform A
NM_004837.4	NP_004828.1	geranylgeranyl pyrophosphate synthase isoform A

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables farnesyltranstransferase activity	IDA IDA: 通过直接分析推断	9741684	GOA
enables farnesyltranstransferase activity	IMP IMP: 通过突变表型推断	32403198	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in isoprenoid metabolic process	IDA IDA: 通过直接分析推断	10026212	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Z disc	IMP IMP: 通过突变表型推断	32403198	GOA
located in cytoplasm	IMP IMP: 通过突变表型推断	32403198	GOA
located in perinuclear region of cytoplasm	IMP IMP: 通过突变表型推断	32403198	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GGPS1 蛋白结构

polyprenyl_synt

0
100
200
300 a.a.

蛋白主名

其他名称

geranylgeranyl pyrophosphate synthase

(2E,6E)-farnesyl diphosphate synthase

GGPS1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	GGPS1	O95749	ATOX1	Homo sapiens	O00244	Y2H Prey Pooling	25416956
种属内	GGPS1	O95749	GGPS1	Homo sapiens	O95749	Y2H Prey Pooling	32296183
种属内	GGPS1	O95749	FAM120A	Homo sapiens	Q9NZB2	Anti Tag CoIP	33961781
种属内	GGPS1	O95749	CCDC85C	Homo sapiens	A6NKD9	Anti Tag CoIP	33961781
种属内	GGPS1	O95749	GGPS1	Homo sapiens	O95749	Validated Y2H	32296183
种属内	GGPS1	O95749	GGPS1	Homo sapiens	O95749	Y2H Array	25416956
种属内	GGPS1	O95749	FAM120A	Homo sapiens	Q9NZB2	Anti Tag CoIP	28514442
种属内	GGPS1	O95749	CCDC85C	Homo sapiens	A6NKD9	Anti Tag CoIP	28514442
种属内	GGPS1	O95749	GGPS1	Homo sapiens	O95749	Y2H Array	32296183
种属内	GGPS1	O95749	GGPS1	Homo sapiens	O95749	Y2H Array	31515488

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 GGPS1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70224	GGPS1 Protein, Human (His)	O95749 (M1-E300)	≥95%

关联疾病

疾病名称

别名

Muscular Dystrophy, Congenital Hearing Loss, And Ovarian Insufficiency Syndrome

MDHLO

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Myasthenic Syndrome, Congenital, 2c, Associated With Acetylcholine Receptor Deficiency

Congenital Myasthenic Syndrome 2c	CMS2C
Congenital Myasthenic Syndrome 2c Associated With Acetylcholine Receptor Deficiency	Myasthenic Syndrome, Congenital, Type 2c, Associated With Acetylcholine Receptor Deficiency

Muscular Dystrophy

Muscular Dystrophies	Congenital Md
Congenital Muscular Dystrophy	Cmd
Mdc	Dystrophy, Muscular
Gower'S Muscular Dystrophy	Progressive Musclular Dystrophy
Pseudohypertrophic Atrophy	Pseudohypertrophic Muscle Paralysis
Pseudohypertrophic Muscular Atrophy	Pseudohypertrophic Muscular Dystrophy
Pseudohypertrophic Paralysis	Pseudomuscular Hypertrophy

Hyperinsulinism

Hyperinsulinemia

Mammary Paget'S Disease

Paget'S Disease	Mammary Paget Disease
Paget'S Disease Of The Breast	Paget Disease Of The Breast
Paget'S Disease Of The Nipple	Paget'S Disease, Mammary
Paget Cell Neoplasm	Paget Disease Of The Nipple
Pagets Disease Mammary	Osteitis Deformans

Porokeratosis

Disseminated Superficial Actinic Porokeratosis	Dsap
Porokeratosis Of Mibelli	Porokeratosis, Disseminated Superficial Actinic
Porokeratosis, Disseminated Superficial Actinic, 1

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Deafness
Sensorineural Hearing Loss Disorder	Hearing Loss, Sensorineural
Central Hearing Loss	High Frequency Deafness
High Frequency Hearing Loss	High-Frequency Hearing Loss
Perceptive Deafness	Perceptive Hearing Loss
Perceptive Hearing Loss Or Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Perrault Syndrome

Gonadal Dysgenesis, Xx Type, With Deafness	Ovarian Dysgenesis With Sensorineural Deafness
Gonadal Dysgenesis, Xx Type	Gonadal Dysgenesis With Auditory Dysfunction, Autosomal Recessive Inheritance
Gonadal Dysgenesis With Sensorineural Deafness, Autosomal Recessive Inheritance	Xx Gonodal Dysgenesis-Deafness Syndrome
Xx Gonodal Dysgenesis-Hearing Loss Syndrome	Gonadal Dysgenesis Xx Type Deafness

Breast Adenocarcinoma

Mammary Adenocarcinoma

Adenocarcinoma Of Breast

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05402	GGPS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	GGPS1	VGNC	VGNC:99960
Canis familiaris	GGPS1	VGNC	VGNC:41201
Felis catus	GGPS1	VGNC	VGNC:62539
Rattus norvegicus	GGPS1	RGD	RGD:1359680
Mus musculus	GGPS1	MGD	MGI:1341724
Bos taurus	GGPS1	VGNC	VGNC:29343
Others	GGPS1	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

GGPS1 - geranylgeranyl diphosphate synthase 1 Gene

关于 GGPS1

功能概要

GGPS1 基因产物(5)

GGPS1 蛋白结构

GGPS1 蛋白互作信息

重组 GGPS1 蛋白

关联疾病

直系同源

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GGPS1 - geranylgeranyl diphosphate synthase 1 Gene

关于 GGPS1

功能概要

GGPS1 基因产物(5)

GGPS1 蛋白结构

GGPS1 蛋白互作信息

重组 GGPS1 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z