2. Gene
  3. THEMIS2 - thymocyte selection associated family member 2 Gene

THEMIS2 - thymocyte selection associated family member 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：胸腺细胞选择相关家族成员 2

种属: Homo sapiens

同用名: ICB1; ICB-1; C1orf38

基因 ID: 9473 | 基因类型: protein coding

关于 THEMIS2

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:27,872,544-27,886,675 (from NCBI)

This gene has 11 transcripts (splice variants), 202 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 58.1), spleen (RPKM 43.6) and 17 other tissues.

功能概要

预计参与 T 细胞受体信号通路和 B 细胞活化的调节。预计在细胞质和细胞核中有活性。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to be involved in T cell receptor signaling pathway and regulation of B cell activation. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

THEMIS2 基因产物(5)

mRNA Protein Name
NM_001039477.3 NP_001034566.1 protein THEMIS2 isoform 2
NM_001105556.3 NP_001099026.1 protein THEMIS2 isoform 3
NM_001286113.2 NP_001273042.1 protein THEMIS2 isoform 4
NM_001286115.2 NP_001273044.1 protein THEMIS2 isoform 5
NM_004848.4 NP_004839.2 protein THEMIS2 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

THEMIS2 蛋白结构

CABIT

CABIT: Cell-cycle sustaining, positive selection, (18 - 249)

CABIT

CABIT: Cell-cycle sustaining, positive selection, (286 - 520)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 643 a.a.
蛋白主名 其他名称

protein THEMIS2

basement membrane-induced

THEMIS2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
THEMIS2 Q5TEJ8 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
31515488
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Endometrial Adenocarcinoma

Endometrial Endometrioid Adenocarcinoma

Endometrial Adenoacanthoma

Endometrial Endometrioid Adenocarcinoma, Variant With Squamous Differentiation

Adenocarcinoma Of Endometrium

Adenocarcinoma Of The Endometrium

Adenocarcinoma Of Uterus

Endometrial Endometrioid Adenocarcinoma With Squamous Differentiation

Endometrioid Adenoma Or Carcinoma

Endometrioid Adenomas And Carcinomas

Endometrioid Carcinoma Of Endometrium

Endometrium Adenocarcinoma
Xia-Gibbs Syndrome

Ahdc1-Related Intellectual Disability-Obstructive Sleep Apnea-Mild Dysmorphism Syndrome

XIGIS

Mrd25

Ahdc1-Related Intellectual Disability - Obstructive Sleep Apnea - Mild Dysmorphism Syndrome

Mental Retardation, Autosomal Dominant 25, Formerly

Mrd25, Formerly

Autosomal Dominant Mental Retardation 25

Autosomal Dominant Intellectual Disability 25

Xgs
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14489 THEMIS2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus THEMIS2 RGD RGD:1561016
Bos taurus THEMIS2 VGNC VGNC:35836
Mus musculus THEMIS2 MGD MGI:2446213
Macaca mulatta THEMIS2 VGNC VGNC:78397
Canis familiaris THEMIS2 VGNC VGNC:47344
Felis catus THEMIS2 VGNC VGNC:66162
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z