2. Gene
  3. ENTPD5 - ectonucleoside triphosphate diphosphohydrolase 5 (inactive) Gene

ENTPD5 - ectonucleoside triphosphate diphosphohydrolase 5 (inactive) Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：外核苷三磷酸二磷酸水解酶 5 (无活性)

种属: Homo sapiens

同用名: PCPH; CD39L4; NTPDase-5

基因 ID: 957 | 基因类型: protein coding

关于 ENTPD5

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:73,955,329-74,019,288 (from NCBI)

This gene has 8 transcripts (splice variants), 275 orthologues and 7 paralogues. Broad expression in liver (RPKM 43.1), colon (RPKM 29.4) and 18 other tissues.

功能概要

该基因编码的蛋白质类似于 E 型核苷酸酶 (NTPases) /ecto-ATPase/apyrases。 NTP 酶，如 CD39，介导细胞外核苷酸的分解代谢。 ENTPD5 包含 4 个腺苷三磷酸双磷酸酶保守区，这是 NTP 酶的特征。[RefSeq 提供，2009 年 1 月]

The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. [provided by RefSeq, Jan 2009]

ENTPD5 基因产物(14)

mRNA Protein Name
NM_001249.5 NP_001240.1 nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor
NM_001321984.2 NP_001308913.1 nucleoside diphosphate phosphatase ENTPD5 isoform 2 precursor
NM_001321985.3 NP_001308914.1 nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor
NM_001321986.3 NP_001308915.1 nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor
NM_001321987.3 NP_001308916.1 nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor
NM_001321988.3 NP_001308917.1 nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor
NM_001330189.2 NP_001317118.1 nucleoside diphosphate phosphatase ENTPD5 isoform 3 precursor
NM_001382256.1 NP_001369185.1 nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor
NM_001382257.1 NP_001369186.1 nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor
NM_001382258.1 NP_001369187.1 nucleoside diphosphate phosphatase ENTPD5 isoform 4 precursor
NM_001382259.1 NP_001369188.1 nucleoside diphosphate phosphatase ENTPD5 isoform 3 precursor
NM_001382260.1 NP_001369189.1 nucleoside diphosphate phosphatase ENTPD5 isoform 3 precursor
NM_001382262.1 NP_001369191.1 nucleoside diphosphate phosphatase ENTPD5 isoform 5 precursor
NM_001382263.1 NP_001369192.1 nucleoside diphosphate phosphatase ENTPD5 isoform 6 precursor
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ADP phosphatase activity IDA
IDA: 通过直接分析推断
10400613 GOA
enables CDP phosphatase activity IDA
IDA: 通过直接分析推断
10400613 GOA
enables GDP phosphatase activity IDA
IDA: 通过直接分析推断
10400613 GOA
enables IDP phosphatase activity IDA
IDA: 通过直接分析推断
15698960 GOA
enables UDP phosphatase activity IDA
IDA: 通过直接分析推断
10400613 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular region IDA
IDA: 通过直接分析推断
15698960 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
10400613 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ENTPD5 蛋白结构

GDA1_CD39

GDA1_CD39: GDA1/CD39 (nucleoside phosphatase) family (46 - 424)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 428 a.a.
蛋白主名 其他名称

nucleoside diphosphate phosphatase ENTPD5

CD39 antigen-like 4

ENTPD5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ENTPD5 O75356 HTT Homo sapiens P42858
Y2H Array
32814053
种属内
ENTPD5 O75356 HTT Homo sapiens P42858
Validated Y2H
32814053
种属内
ENTPD5 O75356 HTT Homo sapiens P42858
Y2H Pooling
32814053
种属内
ENTPD5 O75356 MXI1 Homo sapiens P50539
Y2H Array
25416956
种属内
ENTPD5 O75356 MXI1 Homo sapiens P50539
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ENTPD5 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76905 ENTPD5 Protein, Human (sf9, His) O75356 (V21-H428) ≥95%

关联疾病

疾病名称 别名
Coenzyme Q10 Deficiency, Primary, 6

Familial Steroid-Resistant Nephrotic Syndrome With Sensorineural Deafness

COQ10D6

Primary Coenzyme Q10 Deficiency 6

Familial Steroid-Resistant Nephrotic Syndrome With Sensorineural Hearing Loss

Srns With Sensorineural Deafness

Steroid-Resistant Nephrotic Syndrome With Sensorineural Deafness

Coenzyme Q10 Deficiency, Primary, Type 6
Lutembacher'S Syndrome

Lutembacher Syndrome

Lutembacher'S Anomaly
Scrapie
Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly

Mcph

True Microcephaly

Microcephalia Vera

Microcephaly Vera

Microcephaly Primary Hereditary

Microcephaly, Primary, Autosomal Recessive

Primary Microcephaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04399 ENTPD5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ENTPD5 VGNC VGNC:40384
Rattus norvegicus ENTPD5 RGD RGD:735219
Felis catus ENTPD5 VGNC VGNC:80977
Mus musculus ENTPD5 MGD MGI:1321385
Bos taurus ENTPD5 VGNC VGNC:28511
Others ENTPD5 NCBI
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