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  3. MXI1 - MAX interactor 1, dimerization protein Gene

MXI1 - MAX interactor 1, dimerization protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：MAX interactor 1，二聚化蛋白

种属: Homo sapiens

同用名: MXI; MAD2; MXD2; bHLHc11

基因 ID: 4601 | 基因类型: protein coding

关于 MXI1

Cytogenetic location: 10q25.2 Genomic coordinates (GRCh38): 10:110,207,605-110,287,365 (from NCBI)

This gene has 38 transcripts (splice variants), 258 orthologues, 4 paralogues and is associated with 1 phenotype. Ubiquitous expression in ovary (RPKM 23.6), brain (RPKM 22.2) and 25 other tissues.

功能概要

产生致癌转录因子的 c-Myc 基因的表达在正常细胞中受到严格调控，但在人类癌症中经常失调。由该基因编码的蛋白质是一种转录抑制因子，被认为可以负向调节 MYC 功能，因此是一种潜在的肿瘤抑制因子。这种蛋白质通过竞争 MAX 来抑制 MYC 的转录活性，MAX 是另一种基本的螺旋-环-螺旋蛋白，它与 MYC 结合并且是其功能所必需的。该基因的缺陷经常在前列腺肿瘤患者中发现。已经描述了编码不同亚型的三种可变剪接转录本。可能存在其他可变剪接的转录本，但这些转录本的产物尚未通过实验验证。[RefSeq 提供，2008 年 7 月]

Expression of the c-Myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]

MXI1 基因产物(3)

mRNA Protein Name
NM_001008541.1 NP_001008541.1 max-interacting protein 1 isoform c
NM_005962.5 NP_005953.4 max-interacting protein 1 isoform a
NM_130439.3 NP_569157.2 max-interacting protein 1 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
contributes to DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
11875718 GOA
contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
8425219 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9184233 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
11875718 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase II transcription regulator complex IDA
IDA: 通过直接分析推断
8425219 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MXI1 蛋白结构

HLH

HLH: Helix-loop-helix DNA-binding domain (69 - 120)

  • 0
  • 100
  • 200
  • 228 a.a.
蛋白主名 其他名称

max-interacting protein 1

MAX dimerization protein 2

MXI1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra MXI1 P50539 MAX Homo sapiens P61244-2
Y2H Prey Pooling
25416956
Intra MXI1 P50539 ENTPD5 Homo sapiens O75356
Y2H Prey Pooling
25416956
Intra MXI1 P50539 MAX Homo sapiens P61244
Y2H
9184233
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Neurofibrosarcoma

Neurosarcoma

Malignant Peripheral Nerve Sheath Tumor
Prostatic Adenoma

Prostatic Hyperplasia

Adenoma - Prostate

Adenoma Of Prostate

Benign Adenoma Of Prostate

Prostate Adenoma

Benign Prostatic Hyperplasia
Shigellosis

Dysentery, Bacillary

Bacillary Dysentery

Shigella Boydii Infectious Disease

Shigella Flexneri Infectious Disease

Shigella Gastroenteritis

Shigella Sonnei Infectious Disease

Shigella Infections
Small Cell Carcinoma

Small Cell Carcinoma, Intermediate Cell

Intermediate Cell Small Cell Carcinoma

Small Cell Carcinoma - Intermediate Cell

Small Cell Carcinoma Of Lung

Carcinoma, Small Cell
Glanders

Farcy Pipes

Infection Due To Pseudomonas Mallei

Burkholderia Mallei

Burkholderia Mallei Infection

Equina

Equine Glanders

Farcy

Farcy Buds

Farcy Cords

Infection Due To Actinobacillus Mallei

Infection Due To Malleomyces Mallei

Maliasmus

Malleus

Farce

Actinobacillosis

Actinobacillus Infection
Basal Cell Carcinoma

Basal Cell Cancer

Basal Cell Neoplasm

Basal Cell Carcinoma Of Skin

Malignant Basal Cell Tumor

Basal Cell Tumor

Epithelioma Basal Cell

Malignant Basal Cell Neoplasm

Rodent Ulcer

Carcinoma Basal Cell

Neoplasms, Basal Cell

Basal Cell Carcinomas

Experimental Organism Basal Cell Carcinoma

Nodulo-Ulcerative Basal Cell Carcinoma

Basalioma

Basal Cell Epithelioma Of Skin

Bcc - [Basal Cell Carcinoma] Of Skin

Rodent Ulcer Of Skin

Rodent Ulcer Of Unspecified Site

Basal Cell Epithelioma Of Unspecified Site
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08864 MXI1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus MXI1 VGNC VGNC:31773
Canis familiaris MXI1 VGNC VGNC:43515
Felis catus MXI1 VGNC VGNC:68366
Mus musculus MXI1 MGD MGI:97245
Macaca mulatta MXI1 VGNC VGNC:75087
Rattus norvegicus MXI1 RGD RGD:3128
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