2. Gene
  3. PDIA4 - protein disulfide isomerase family A member 4 Gene

PDIA4 - protein disulfide isomerase family A member 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白质二硫键异构酶家族 A 成员 4

种属: Homo sapiens

同用名: ERP70; ERP72; ERp-72

基因 ID: 9601 | 基因类型: protein coding

关于 PDIA4

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:149,003,051-149,028,505 (from NCBI)

This gene has 4 transcripts (splice variants), 212 orthologues and 13 paralogues. Broad expression in thyroid (RPKM 166.5), liver (RPKM 67.6) and 24 other tissues.

功能概要

该基因编码内质网 (ER) 蛋白二硫化物异构酶 (PDI) 家族的成员，该蛋白催化蛋白质折叠和硫醇-二硫化物交换反应。编码的蛋白质具有一个 N 端 ER 信号序列、三个催化活性硫氧还蛋白 (TRX) 结构域、两个 TRX 样结构域和一个 C 端 ER 保留序列。当该蛋白与亲环蛋白 B 结合时，可提高免疫球蛋白 G 分子间二硫键和抗体组装的速率。[RefSeq 提供，2016 年 12 月]

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. This protein, when bound to Cyclophilin B, enhances the rate of immunoglobulin G intermolecular disulfide bonding and antibody assembly. [provided by RefSeq, Dec 2016]

PDIA4 基因产物(3)

mRNA Protein Name
NM_001371244.1 NP_001358173.1 protein disulfide-isomerase A4 isoform 1 precursor
NM_001371245.1 NP_001358174.1 protein disulfide-isomerase A4 isoform 3 precursor
NM_004911.5 NP_004902.1 protein disulfide-isomerase A4 isofrom 2 precursor
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16287128 GOA
enables protein-disulfide reductase activity IDA
IDA: 通过直接分析推断
16677074 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
19995400 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
19995400 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PDIA4 蛋白结构

Thioredoxin

Thioredoxin: Thioredoxin (64 - 165)

Thioredoxin

Thioredoxin: Thioredoxin (179 - 280)

Thioredoxin_6

Thioredoxin_6: Thioredoxin-like domain (312 - 503)

Thioredoxin

Thioredoxin: Thioredoxin (527 - 634)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 645 a.a.
蛋白主名 其他名称

protein disulfide-isomerase A4

ER protein 70

PDIA4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PDIA4 P13667 KRTAP10-8 Homo sapiens P60410
Validated Y2H
32296183
种属内
PDIA4 P13667 KRTAP12-1 Homo sapiens P59990
Validated Y2H
32296183
种属内
PDIA4 P13667 KRTAP4-11 Homo sapiens Q9BYQ6
Validated Y2H
32296183
种属内
PDIA4 P13667 LCN2 Homo sapiens P80188
Y2H Array
32296183
种属内
PDIA4 P13667 LCN2 Homo sapiens P80188
Y2H Prey Pooling
32296183
种属内
PDIA4 P13667 LCN2 Homo sapiens P80188
Validated Y2H
32296183
种属内
PDIA4 P13667 PPIB Homo sapiens P23284
Crosslink
30021884
种属间
PDIA4 P13667 q76353_9hiv1 Human immunodeficiency virus Q76353
Pull Down
22190034
种属内
PDIA4 P13667 EMC7 Homo sapiens Q9NPA0
Anti Tag CoIP
33961781
种属内
PDIA4 P13667 EMC7 Homo sapiens Q9NPA0
Anti Tag CoIP
28514442
种属内
PDIA4 P13667 P23284-PRO_0000025479 Homo sapiens P23284-PRO_0000025479
Pull Down
22665516
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PDIA4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71113 PDIA4 Protein, Human (HEK293, His) P13667 (V21-L645) ≥95%

关联疾病

疾病名称 别名
Multiple Epiphyseal Dysplasia

Med

Polyepiphyseal Dysplasia

Edm

Epiphyseal Dysplasia, Multiple, 1

Epiphyseal Dysplasia, Multiple, 2

Epiphyseal Dysplasia, Multiple, 3

Epiphyseal Dysplasia, Multiple, 4

Epiphyseal Dysplasia, Multiple, 5

Epiphyseal Dysplasia, Multiple

Edm1

Edm2

Edm3

Edm4

Edm5

Epiphyseal Dysplasia, Fairbank Type

Epiphyseal Dysplasia, Ribbing Type

Multiple Epiphyseal Dysplasia, Autosomal Dominant

Multiple Epiphyseal Dysplasia, Autosomal Recessive

Rmed

Dysplasia, Epiphyseal, Multiple

Osteochondrodysplasias
Congenital Hypothyroidism

Cretinism

Neonatal Hypothyroidism

Ch

Cht

Congenital Myxedema

Myxedema, Congenital

Endemic Cretinism

Congenital Iodine-Deficiency Syndrome

Fetal Iodine Deficiency Syndrome

Congenital Iodine-Deficiency Hypothyroidism Nos
Ovarian Dysgenesis 2

Premature Ovarian Failure 4

ODG2

Ovarian Dysgenesis, Hypergonadotropic, X-Linked

Ovarian Failure, Hypergonadotropic, Due To Ovarian Dysgenesis

Ovarian Failure Hypergonadotropic Due To Ovarian Dysgenesis

X-Linked Hypergonadotropic Ovarian Dysgenesis

POF4

Dysgenesis, Ovarian, Type 2
Epiphyseal Dysplasia, Multiple, 5

EDM5

Multiple Epiphyseal Dysplasia 5

Bhmed

Multiple Epiphyseal Dysplasia Type 5

Multiple Epiphyseal Dysplasia, Matn3-Related

Microepiphyseal Dysplasia, Bilateral Hereditary

Bilateral Hereditary Microepiphyseal Dysplasia

Multiple Epiphyseal Dysplasia Matn3-Related

Epiphyseal Dysplasia Multiple 5

Multiple Epiphyseal Dysplasia, Matn3 Related

Bilateral Hereditary Micro-Epiphyseal Dysplasia

Med5

Polyepiphyseal Dysplasia Type 5

Dysplasia, Epiphyseal, Multiple, Type 5
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-122895 E64FC26 98.10% 否
HY-122895A (E/Z)-E64FC26 98.09% 否
HY-RS10269 PDIA4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus PDIA4 VGNC VGNC:64084
Mus musculus PDIA4 MGD MGI:104864
Macaca mulatta PDIA4 VGNC VGNC:84750
Canis familiaris PDIA4 VGNC VGNC:44377
Bos taurus PDIA4 VGNC VGNC:32698
Rattus norvegicus PDIA4 RGD RGD:619835
Others PDIA4 NCBI
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