HERPUD1 - homocysteine inducible ER protein with ubiquitin like domain 1 Gene

中文名称：具有泛素样结构域 1 的同型半胱氨酸诱导型 ER 蛋白

种属: Homo sapiens

同用名: SUP; HERP; Mif1

关于 HERPUD1

功能概要

未折叠蛋白在内质网 (ER) 中的积累会触发 ER 应激反应。这种反应包括抑制翻译以防止未折叠蛋白质的进一步积累、参与多肽折叠的蛋白质表达增加，称为未折叠蛋白质反应 (UPR) ，以及通过 ER 相关蛋白质降解 (ERAD) 破坏错误折叠的蛋白质) 系统。该基因可能在 UPR 和 ERAD 中发挥作用。它的表达是由 UPR 诱导的，在其启动子区域有一个内质网应激反应元件，而编码的蛋白质有一个 N 端泛素样结构域，可以与 ERAD 系统相互作用。这种蛋白质已被证明与早老素蛋白质相互作用，并在其过度表达后增加淀粉样蛋白-β 的水平。该基因的可变剪接产生编码不同亚型的多个转录变体。所有转录变体的全长性质尚未确定。[RefSeq 提供，2013 年 1 月]

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined. [provided by RefSeq, Jan 2013]