2. Gene
  3. ARHGAP25 - Rho GTPase activating protein 25 Gene

ARHGAP25 - Rho GTPase activating protein 25 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Rho GTP 酶激活蛋白 25

种属: Homo sapiens

同用名: KAIA0053; HEL-S-308

基因 ID: 9938 | 基因类型: protein coding

关于 ARHGAP25

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:68,710,544-68,826,833 (from NCBI)

This gene has 17 transcripts (splice variants), 206 orthologues and 2 paralogues. Broad expression in lymph node (RPKM 20.1), spleen (RPKM 18.9) and 23 other tissues.

功能概要

ARHGAP，例如 ARHGAP25，编码 Rho GTP 酶的负调节因子 (参见 ARHA；MIM 165390) ，其与肌动蛋白重塑、细胞极性和细胞迁移有关 (Katoh 和 Katoh，2004 [PubMed 15254788]) 。[OMIM 提供， 2008 年 3 月]

ARHGAPs, such as ARHGAP25, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).[supplied by OMIM, Mar 2008]

ARHGAP25 基因产物(7)

mRNA Protein Name
NM_001007231.3 NP_001007232.2 rho GTPase-activating protein 25 isoform a
NM_001166276.2 NP_001159748.1 rho GTPase-activating protein 25 isoform c
NM_001166277.2 NP_001159749.1 rho GTPase-activating protein 25 isoform d
NM_001364819.1 NP_001351748.1 rho GTPase-activating protein 25 isoform e
NM_001364820.1 NP_001351749.1 rho GTPase-activating protein 25 isoform f
NM_001364821.1 NP_001351750.1 rho GTPase-activating protein 25 isoform g
NM_014882.3 NP_055697.1 rho GTPase-activating protein 25 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin filament organization IMP
IMP: 通过突变表型推断
26465210 GOA
involved in negative regulation of small GTPase mediated signal transduction IMP
IMP: 通过突变表型推断
26465210 GOA
involved in phagocytosis, engulfment IMP
IMP: 通过突变表型推断
26465210 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in phagocytic cup IDA
IDA: 通过直接分析推断
26465210 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARHGAP25 蛋白结构

PH

PH: PH domain (48 - 148)

RhoGAP

RhoGAP: RhoGAP domain (178 - 326)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 646 a.a.
蛋白主名 其他名称

rho GTPase-activating protein 25

epididymis secretory protein Li 308

ARHGAP25 抗体

目录号 产品名 应用 反应物种
HY-P82404 ARHGAP25 Antibody (YA2149) WB, IHC-P Human, Rat

关联疾病

疾病名称 别名
Rhabdomyosarcoma 2

Alveolar Rhabdomyosarcoma

Rhabdomyosarcoma, Alveolar

Rhabdomyosarcoma Alveolar

RMS2

Rmsa

Rhabdomyosarcoma 2, Alveolar

Alveolar Childhood Rhabdomyosarcoma

Arms

Rhabdomyosarcoma, Type 2
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00925 ARHGAP25 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus ARHGAP25 VGNC VGNC:26083
Macaca mulatta ARHGAP25 VGNC VGNC:69921
Rattus norvegicus ARHGAP25 RGD RGD:1562105
Mus musculus ARHGAP25 MGD MGI:2443687
Felis catus ARHGAP25 VGNC VGNC:59882
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