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  2. CDC34 - cell division cycle 34, ubiqiutin conjugating enzyme Gene

CDC34 - cell division cycle 34, ubiqiutin conjugating enzyme Gene

中文名称:细胞分裂周期 34,泛素结合酶

种属: Homo sapiens

同用名: UBC3; UBCH3; UBE2R1; E2-CDC34

基因 ID: 997 | 基因类型: protein coding

关于 CDC34

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:531,760-542,087 (from NCBI)

This gene has 7 transcripts (splice variants), 126 orthologues and 24 paralogues. Ubiquitous expression in testis (RPKM 23.4), placenta (RPKM 14.2) and 25 other tissues.

功能概要

该基因编码的蛋白质是泛素结合酶家族的成员。泛素结合酶催化泛素与其他蛋白质的共价连接。这种蛋白质是大型多蛋白复合物的一部分,它是泛素介导的细胞周期 G1 调节因子降解和 DNA 复制启动所必需的。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a member of the ubiquitin-conjugating Enzyme family. Ubiquitin-conjugating Enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. [provided by RefSeq, Jul 2008]

CDC34 基因产物(1)

mRNA Protein Name
NM_004359.2 NP_004350.1 ubiquitin-conjugating enzyme E2 R1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10373550 GOA
enables ubiquitin conjugating enzyme activity IDA
IDA: 通过直接分析推断
20061386 GOA
enables ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
10373550 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to interferon-beta IMP
IMP: 通过突变表型推断
24882218 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
10373550 GOA
involved in protein K48-linked ubiquitination IDA
IDA: 通过直接分析推断
20061386 GOA
involved in protein polyubiquitination IDA
IDA: 通过直接分析推断
20347421 GOA
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
10373550 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CDC34 蛋白结构

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (14 - 154)

  • 0
  • 100
  • 200
  • 236 a.a.
蛋白主名 其他名称

ubiquitin-conjugating enzyme E2 R1

(E3-independent) E2 ubiquitin-conjugating enzyme R1

重组 CDC34 蛋白

目录号 产品名 蛋白编号 纯度
HY-P79448 UBE2R1/CDC34 Protein, Human (Sf9, His, Strep) P49427 (A2-S236) ≥95%

直系同源

种属 基因名 来源 基因 ID
Felis catus CDC34 VGNC VGNC:60654
Mus musculus CDC34 MGD MGI:102657
Bos taurus CDC34 VGNC VGNC:27066
Rattus norvegicus CDC34 RGD RGD:1305411
Canis familiaris CDC34 VGNC VGNC:38993
Macaca mulatta CDC34 VGNC VGNC:108493
Others CDC34 NCBI