1. Apoptosis
  2. Apoptosis
  3. GL-331

GL-331 是一种有效的抗癌剂。GL-331 在体外和体内淋巴瘤系统中均表现出更有效的抗癌活性。

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GL-331 Chemical Structure

GL-331 Chemical Structure

CAS No. : 127882-73-9

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规格 是否有货
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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GL-331 is a potent anti-cancer agent. GL-331 has demonstrated more efficacious anti-cancer activity in both the in vitro and in vivo lymphoma systems[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
0.113 μg/mL
Compound: GL-331
Cytotoxicity against human A549 cells by SRB assay
Cytotoxicity against human A549 cells by SRB assay
[PMID: 22658864]
A549 IC50
15.8 nM
Compound: Ref 34, Cpd 4
Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay
[PMID: 32992133]
DU-145 IC50
0.8 μg/mL
Compound: GL-331
Cytotoxicity against human DU145 cells by SRB assay
Cytotoxicity against human DU145 cells by SRB assay
[PMID: 22658864]
H9 EC50
< 0.00128 μM
Compound: 15
Evaluation for anti-HIV activity using T cell line (H9).
Evaluation for anti-HIV activity using T cell line (H9).
10.1016/S0960-894X(97)10108-1
KB ED50
0.2 μg/mL
Compound: 63, NSC-628679
Cytotoxicity against human KB cells after 72 hrs by MTT assay
Cytotoxicity against human KB cells after 72 hrs by MTT assay
[PMID: 20187635]
KB ED50
0.2 μg/mL
Compound: 6
Dose required to cause reduction in human nasopharyngeal KB cancer cells after 3 days incubation
Dose required to cause reduction in human nasopharyngeal KB cancer cells after 3 days incubation
[PMID: 15456257]
KB IC50
0.49 μM
Compound: 63, NSC-628679
Cytotoxicity against human KB cells after 72 hrs by MTT assay
Cytotoxicity against human KB cells after 72 hrs by MTT assay
[PMID: 20187635]
KB IC50
0.819 μg/mL
Compound: GL-331
Cytotoxicity against human KB cells by SRB assay
Cytotoxicity against human KB cells by SRB assay
[PMID: 22658864]
KB ED50
1.5 μM
Compound: 4
Effective dose required for inhibition of KB-7d cell replication after 3 days of continuous treatment
Effective dose required for inhibition of KB-7d cell replication after 3 days of continuous treatment
[PMID: 15125972]
KB ED50
2 μg/mL
Compound: 6
Dose required for reduction in human nasopharyngeal KB-7d cancer cells after 3 days incubation
Dose required for reduction in human nasopharyngeal KB-7d cancer cells after 3 days incubation
[PMID: 15456257]
KB IC50
3 μM
Compound: 63, NSC-628679
Cytotoxicity against human vincristine-resistant KB cells after 72 hrs by MTT assay
Cytotoxicity against human vincristine-resistant KB cells after 72 hrs by MTT assay
[PMID: 20187635]
MCF7 IC50
15.8 nM
Compound: Ref 34, Cpd 4
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay
[PMID: 32992133]
PC-3 IC50
15.8 nM
Compound: Ref 34, Cpd 4
Antiproliferative activity against human PC3 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human PC3 cells incubated for 72 hrs by MTT assay
[PMID: 32992133]
体外研究
(In Vitro)

GL-331 在杀死癌细胞方面比 VP-16 (HY-13629) 更有效。即使在 MDR-1 过表达细胞系(如 HCC36 和 SW620)中,GL-331 也具有更强的细胞杀伤活性。其更高的细胞毒性可以归因于诱导细胞凋亡的能力增强[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

520.49

Formula

C27H24N2O9

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

GL-331 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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GL-331
目录号:
HY-19188
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