2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. Glecirasib

Glecirasib  (Synonyms: JAB-21822; KRAS G12C inhibitor 36)

目录号: HY-143589 纯度: 98.89%
COA 产品使用指南

摩尔计算器

Glecirasib (Compound 1-2; JAB-21822) 是具有口服活性且有效的 KRAS G12C 抑制剂。Ras 蛋白家族是一种重要的细胞内信号分子，在生长发育中起重要作用。Glecirasib 具有研究 KRAS G12C 介导的癌症的潜力。

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Glecirasib Chemical Structure

Glecirasib Chemical Structure

CAS No. : 2657613-87-9

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规格 价格 是否有货 数量
1 mg ￥6800
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Glecirasib 相关抗体

Top Publications Citing Use of Products

查看 Ras 亚型特异性产品:

查看所有亚型
K-Ras H-Ras N-Ras Ras

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Glecirasib (Compound 1-2; JAB-21822) is an orally active and potent inhibitor of KRAS G12C. The Ras family of proteins is an important intracellular signaling molecule that plays an important role in growth and development. Glecirasib has the potential for the research of KRAS G12C-mediated cancer[1][2][3][4].

体内研究
(In Vivo)

Glecirasib (10 mg/kg，口服，每天一次，持续约 3 周) 在 NCI-H1373 异种移植小鼠模型中抑制肿瘤生长[1][3]。
Glecirasib (400 mg/kg，口服，每天一次，持续 22 天) 在 NCI-H1373 异种移植小鼠模型中对体重没有影响，显示出良好安全性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NCI-H1373 xenograft mice model[1]
Dosage: 400 mg/kg
Administration: p.o., daily for 22 days
Result: Had no significant change on the weight of the mice.
Animal Model: NCI-H1373 xenograft mice model[1]
Dosage: 10 mg/kg
Administration: p.o., daily for ~3 weeks
Result: Decreased the tumor volume in the NCI-H1373 xenograft mice.
分子量

640.03

Formula

C31H26ClF4N7O2
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 98.89%

COA (200 KB) HNMR (225 KB) RP-HPLC (142 KB) LCMS (110 KB)

产品使用指南 (1538 KB)
参考文献

Glecirasib 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glecirasib2657613-87-9JAB-21822 KRAS G12C inhibitor 36JAB21822JAB 21822RasKRAS G12CintracellulargrowthcancerInhibitorinhibitorinhibit

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