1. GPCR/G Protein
  2. GLP Receptor
  3. GLP-1R/GIPR agonist-1 (soduim)

GLP-1R/GIPR agonist-1 (soduim) 

目录号: HY-P10302A 纯度: 96.55%
COA 产品使用指南

GLP-1R/GIPR agonist-1 soduim 是 GLP-1R/GIPR agonist-1 (HY-P10302) 的钠盐形式。GLP-1R/GIPR agonist-1 soduim 是胰高血糖素样肽-1 受体 (GLP-1R, EC50 为 0.57 nM) 和葡萄糖依赖性胰岛素释放肽受体 (GIPR, EC50 为 0.75 nM) 的双重激动剂。GLP-1R/GIPR agonist-1 soduim 通过模仿内源性激素 GLP-1GIP 的作用来降低血糖,增强胰岛素分泌,同时抑制胰高血糖素分泌。GLP-1R/GIPR agonist-1 soduim 可用于糖尿病、肥胖症、非酒精性脂肪性肝炎 (NASH) 等代谢疾病的研究。

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Custom Peptide Synthesis

GLP-1R/GIPR agonist-1 (soduim) Chemical Structure

GLP-1R/GIPR agonist-1 (soduim) Chemical Structure

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规格 价格 是否有货 数量
1 mg ¥1150
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5 mg ¥2900
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10 mg ¥4650
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Other Forms of GLP-1R/GIPR agonist-1 (soduim):

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GLP-1R/GIPR agonist-1 soduim is the sodium salt form of GLP-1R/GIPR agonist-1 (HY-P10302). GLP-1R/GIPR agonist-1 soduim is a dual agonist for glucagon-like peptide-1 receptor (GLP-1R, EC50 is 0.57 nM) and glucose-dependent insulin releasing peptide receptor (GIPR, EC50 is 0.75 nM). GLP-1R/GIPR agonist-1 soduim lowers blood sugar by mimicking the action of endogenous hormones GLP-1 and GIP, enhancing insulin secretion while inhibiting glucagon secretion. GLP-1R/GIPR agonist-1 soduim can be used in the study of metabolic diseases such as diabetes, obesity, and non-alcoholic steatohepatitis (NASH)[1].

IC50 & Target

EC50: 0.57 nM (GLP-1R), 0.75 nM (GIPR)

分子量

4861.38 (free base)

Formula

C220H334N55O69.xNa

性状

固体

颜色

White to off-white

Sequence

His-{Aib}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-{Aib}-Leu-Asp-Lys-Arg-Ala-Ala-Lys(AEEA-AEEA-gammaGlu-C18 diacid)-Asp-Phe-Val-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2

Sequence Shortening

H-{Aib}-QGTFTSDYSK-{Aib}-LDKRAA-K(AEEA-AEEA-gammaGlu-C18 diacid)-DFVEWLKNGGPSSGAPPPS-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
GLP-1R/GIPR agonist-1 (soduim)
目录号:
HY-P10302A
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