2. Anti-infection Stem Cell/Wnt JAK/STAT Signaling
  3. Bacterial STAT
  4. Golotimod TFA

Golotimod TFA  (Synonyms: SCV 07 TFA; Gamma-D-glutamyl-L-tryptophan TFA)

目录号: HY-14743A
产品使用指南

摩尔计算器

Golotimod TFA (SCV 07 TFA) 一种具有抗菌活性的免疫调节肽，可显著提高抗结核研究的功效，刺激胸腺和脾细胞增殖，并改善巨噬细胞功能。Golotimod TFA (SCV 07 TFA) 抑制 STAT3 信号传导并调节接受放疗或放疗与顺铂联合用药的动物模型中口腔粘膜炎的持续时间和严重程度。Golotimod TFA (SCV 07 TFA) 具有用于研究复发性生殖器单纯疱疹病毒 2 型 (HSV-2)的潜力。

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Golotimod TFA Chemical Structure

Golotimod TFA Chemical Structure

CAS No. : 2828433-07-2

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Golotimod TFA (SCV 07 TFA), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod TFA (SCV 07 TFA) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod TFA (SCV 07 TFA) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2)[1][2][3].

IC50 & Target[2]

STAT3

 

体内研究
(In Vivo)

Golotimod (SCV-07) TFA (oral gavage or subcutaneous injection, 100 μg/kg, 5 days) reduces experimental recurrent genital HSV-2 disease by oral administration, more importantly, oral SCV07 after fasting shows a greater reduction in incidence and severity than SCV-07 without fasting in female hartley guinea pigs[1].
Golotimod (SCV-07) TFA (subcutaneous injection, once or twice a day from days 1 to 20, 100 μg/kg) can reduce the severity and duration of acute and split radiation-induced oral mucositis (OM) and short the duration of ulcerative OM in male LVG golden Syrian Hamsters[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Hartley guinea pigs (250-300 g) infected HSV-2[1]
Dosage: 100 μg/kg
Administration: Oral gavage or subcutaneous injection; 5 days
Result: Reduced incidence of lesions from 55% (one week before treatment) to only 18% by oral administration, and showed no significant reduction in disease by subcutaneous injection of SCV-07.
Animal Model: Male LVG golden Syrian Hamsters weighing approximately 80 g with radiation-induced mucositis[3]
Dosage: 10, 100 μg/kg or 1 mg/kg
Administration: Subcutaneous injection; once or twice a day from days 1 to 20
Result: Showed a peak mucositis of 3.0 on day 18 in the control group compared to only 2.2 in the test group, and the mucositis score in the SCV-07 treated hamsters was only 6.3% compared to 28.1% in the control group at dose of 100 μg/kg.
Significantly decreased the severity and duration of oral mucositis (OM) at dose of 10 μg/kg, 100 μg/kg or 1 mg/kg.
Clinical Trial
分子量

447.36

Formula

C18H20F3N3O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Golotimod TFA 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Golotimod2828433-07-2SCV 07Gamma-D-glutamyl-L-tryptophanSCV07SCV-07BacterialSTATimmunomodulating peptideantimicrobialmacrophageoral mucositisHSV-2Inhibitorinhibitorinhibit

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