2. Anti-infection
  3. HIV
  4. gp120-IN-1

gp120-IN-1 (compound 4e) 是一种有效的 HIV-1 gp120 抑制剂，IC50 为 2.2 µM 和 CC 50 的 100.90 µM。gp120-IN-1 显示出抗 HIV-1 活性。gp120-IN-1 在 SUP-T1 细胞中以剂量依赖性方式显示细胞毒性。gp120-IN-1 抑制 gp120 介导的病毒进入细胞。

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gp120-IN-1 Chemical Structure

gp120-IN-1 Chemical Structure

CAS No. : 5948-75-4

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gp120-IN-1 相关抗体

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HIV HIV-1 HIV-2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

gp120-IN-1 (compound 4e) is a potent HIV-1 gp120 inhibitor with an IC50 of 2.2 µM and CC50 of 100.90 µM. gp120-IN-1 shows anti-HIV-1 activity. gp120-IN-1 shows cytotoxicity in a dose dependent manner in SUP-T1 cells. gp120-IN-1 shows inhibition of gp120-mediated virus enter into cells[1].

IC50 & Target[1]

HIV-1

2.2 μM (IC50)

HIV-1

100.90 μM (CC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
786-0 GI50
30 μg/mL
Compound: BA21
Growth inhibition of human 786-0 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human 786-0 cells after 48 hrs by sulforhodamine B assay
[PMID: 22410248]
A549 IC50
> 100 μM
Compound: 4
Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay
[PMID: 31673316]
HCT-116 IC50
> 100 μM
Compound: 4
Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells incubated for 72 hrs by MTT assay
[PMID: 31673316]
HT-29 GI50
34.9 μg/mL
Compound: BA21
Growth inhibition of human HT-29 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human HT-29 cells after 48 hrs by sulforhodamine B assay
[PMID: 22410248]
MCF7 IC50
> 100 μM
Compound: 4
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTT assay
[PMID: 31673316]
MM1.S IC50
> 100 μM
Compound: 4
Antiproliferative activity against human MM1S cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human MM1S cells incubated for 72 hrs by MTT assay
[PMID: 31673316]
NCI/ADR-RES GI50
59.7 μg/mL
Compound: BA21
Growth inhibition of human NCI-ADR-RES cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human NCI-ADR-RES cells after 48 hrs by sulforhodamine B assay
[PMID: 22410248]
NCI-H460 GI50
180.4 μg/mL
Compound: BA21
Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay
[PMID: 22410248]
OVCAR-3 GI50
11 μg/mL
Compound: BA21
Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay
[PMID: 22410248]
PC-3 GI50
72.6 μg/mL
Compound: BA21
Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay
[PMID: 22410248]
SUP-T1 CC50
100.9 μM
Compound: 4e
Cytotoxicity against human SUP-T1 cells assessed as reduction in cell viability measured after 16 hrs by MTT assay
Cytotoxicity against human SUP-T1 cells assessed as reduction in cell viability measured after 16 hrs by MTT assay
[PMID: 34839157]
U-251 GI50
88.3 μg/mL
Compound: BA21
Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B assay
[PMID: 22410248]
分子量

322.38

Formula

C15H18N2O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

gp120-IN-1 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

gp120-IN-15948-75-4HIVHuman immunodeficiency virusSupT1 cellslow cytotoxicityanti-HIV-1HL2/3dose-dependent mannerInhibitorinhibitorinhibit

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