2. Apoptosis
  3. Caspase Apoptosis
  4. GPR

GPR 是一种三氨基酸肽。GPR 可以通过抑制 caspase-3/p53 依赖性细胞凋亡来拯救培养的大鼠海马神经元免受 Aβ 诱导的神经元死亡。GPR 可用于阿尔茨海默病（AD）的研究。

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Custom Peptide Synthesis

GPR Chemical Structure

GPR Chemical Structure

CAS No. : 47295-77-2

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规格 是否有货
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GPR 相关抗体

Top Publications Citing Use of Products

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

生物活性

GPR is a three amino acid peptide. GPR can rescue cultured rat hippocampal neurons from Aβ-induced neuronal death by inhibiting caspase-3/p53 dependent apoptosis. GPR can be used for the research of Alzheimer's disease (AD).

体外研究
(In Vitro)

GPR (1-100 μM; 24 h, 48 h) prevented Aβ-mediated increase in lactate dehydrogenase (LDH) release[1].
GPR (50 μM; 24 h, 48 h) prevents Ah-mediated inhibition of neuronal MTT reduction[1].
GPR (50 μM; 3 days) prevents Aβ-mediated increase in p53-positive cells[1].
GPR (50 μM; 24 h) effectively prevented the Aβ-mediated activation of caspase-3[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GPR 相关抗体:

Apoptosis Analysis[1]

Cell Line: p53-positive cells
Concentration: 50 μM
Incubation Time: 3 days
Result: Inhibited Ah-induced increase in numbers of p53-positive neurons.
Clinical Trial
分子量

328.37

Formula

C13H24N6O4
CAS 号
Sequence Shortening

GPR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

GPR 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GPR47295-77-2CaspaseApoptosisAmyloid β-peptide (Aβ)Alzheimer’s disease (AD)Gly-Pro-Arg (GPR)three amino acid peptidecaspase-3/p53apoptosisInhibitorinhibitorinhibit

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目录号：
HY-P3528
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