2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Ferroptosis Glutathione Peroxidase Reactive Oxygen Species
  4. GPX4-IN-14

GPX4-IN-14 (compound 2c) 是 GPX4 的抑制剂，具有自由基清除活性 (最高清除率为 72.52%) 和体外抗肿瘤增殖活性。GPX4-IN-14 通过抑制 GPX4 蛋白，增加脂质过氧化物水平和细胞内 Reactive Oxygen Species (ROS) 水平，从而诱导铁死亡 (Ferroptosis)，发挥抗肿瘤增殖作用。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

GPX4-IN-14 Chemical Structure

GPX4-IN-14 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

GPX4-IN-14 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GPX4-IN-14 (compound 2c) is an inhibitor of GPX4, with free radical scavenging activity (maximum scavenging rate is 72.52%) and anti-tumor proliferation activity in vitro. GPX4-IN-14 inhibits GPX4 protein, increases lipid peroxide levels and intracellular Reactive Oxygen Species (ROS) levels, thereby inducing ferroptosis and exerting anti-tumor proliferation effects[1].

体外研究
(In Vitro)

GPX4-IN-14 (100 μM，30 min) 有良好的自由基清除活性，最大清除率为 72.52%[1]。
GPX4-IN-14 在 SW480，HCT116，HepG2，MCF-7 细胞中有抗肿瘤增殖活性，IC50 为 5.61 μM，6.59 μM，18.23 μM，9.73 μM，对 LO2 的 IC50 为 11.64 μM[1]。
GPX4-IN-14 (3.3，6.6，13.2 μM，24 h) 在 HCT116 中抑制 GPX4 通路，以剂量依赖性诱导细胞内 ROS 和脂质 ROS 的积累，从而导致铁死亡并抑制线粒体膜电位[1]。
GPX4-IN-14 (3.3，6.6，13.2 μM，24 h) 诱导 HCT116 细胞内铁水平呈剂量依赖性升高[1]。
GPX4-IN-14 (3.3，6.6，13.2 μM，24 h) 在 HCT116 中抑制 GPX4 通路[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GPX4-IN-14 相关抗体:

Immunofluorescence[1]

Cell Line: HCT116
Concentration: 3.3, 6.6, 13.2 μM
Incubation Time: 24 h
Result: Induced significant accumulation of ROS.
Depolarized mitochondrial membrane potential (MMP) in a dose-dependent manner.
Increased lipid ROS levels in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: HCT116
Concentration: 3.3, 6.6, 13.2 μM
Incubation Time: 24 h
Result: Inhibited the expression level of GXP4 and increases the expression of FTH1.

Real Time qPCR[1]

Cell Line: HCT116
Concentration: 3.3, 6.6, 13.2 μM
Incubation Time: 24 h
Result: Inhibited GXP4 expression level.
分子量

572.55

Formula

C26H39NO8Se
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GPX4-IN-14 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GPX4-IN-14FerroptosisGlutathione PeroxidaseReactive Oxygen SpeciesHCT116ROSInhibition of tumor proliferationInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
GPX4-IN-14
目录号：
HY-168011
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z