2. Anti-infection
  3. HIV Reverse Transcriptase
  4. GS-9148

GS-9148 是一种核糖修饰的 HIV-1 核苷酸逆转录酶 (HIV-1 nucleotide reverse transcriptase (RT)) 抑制剂，其 EC50 值为 10.6 µM。GS-9148 对 K65R、L74V 或 M184V RT 突变表现出抗逆转录病毒活性。

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GS-9148 Chemical Structure

GS-9148 Chemical Structure

CAS No. : 875608-25-6

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GS-9148 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GS-9148 is a ribose-modified HIV-1 nucleotide reverse transcriptase (RT) inhibitor with an EC50 value of 10.6 µM. GS-9148 shows antiretroviral activity for K65R, L74V, or M184V RT mutation[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO CC50
≥ 4.5 μM
Compound: GS-9148
Ratio of CC50 for CHO cells to CC50 for CHO cells expressing hOAT1 after 120 hrs by Cell-Titer Glo assay
Ratio of CC50 for CHO cells to CC50 for CHO cells expressing hOAT1 after 120 hrs by Cell-Titer Glo assay
[PMID: 19001108]
CHO CC50
≥ 95 μM
Compound: GS-9148
Cytotoxicity against CHO cells expressing hOAT1 after 120 hrs by Cell-Titer Glo assay
Cytotoxicity against CHO cells expressing hOAT1 after 120 hrs by Cell-Titer Glo assay
[PMID: 19001108]
CHO CC50
182 μM
Compound: GS-9148
Cytotoxicity against CHO cells after 120 hrs by Cell-Titer Glo assay
Cytotoxicity against CHO cells after 120 hrs by Cell-Titer Glo assay
[PMID: 19001108]
MT2 CC50
> 1000 μM
Compound: 3, GS-9148
Cytotoxicity against human MT2 cells after 5 days
Cytotoxicity against human MT2 cells after 5 days
[PMID: 19179082]
MT2 CC50
> 100000 nM
Compound: 4, 2'-Fd4AP, GS-9148
Cytotoxicity against human MT2 cells after 5 days by XTT assay
Cytotoxicity against human MT2 cells after 5 days by XTT assay
[PMID: 20409721]
MT2 EC50
10600 nM
Compound: 4, 2'-Fd4AP, GS-9148
Antiviral activity against HIV1 3B infected in human MT2 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by XTT assay
Antiviral activity against HIV1 3B infected in human MT2 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by XTT assay
[PMID: 20409721]
MT2 EC50
12 μM
Compound: 3, GS-9148
Antiviral activity against HIV1 3a infected human MT2 cells assessed as inhibition of viral-induced cytopathic effect after 3 days by XTT assay
Antiviral activity against HIV1 3a infected human MT2 cells assessed as inhibition of viral-induced cytopathic effect after 3 days by XTT assay
[PMID: 19179082]
分子量

331.20

Formula

C10H11FN5O5P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GS-9148 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GS-9148875608-25-6GS9148GS 9148HIVReverse TranscriptaseHuman immunodeficiency virusMT-2 cellsantiretroviralK65RL74VM184VInhibitorinhibitorinhibit

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目录号：
HY-122018
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