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  4. GSK 1842799 hydrochloride

GSK 1842799 hydrochloride是一种选择性 S1P1 受体激动剂，具有强效激动剂活性，并且选择性优于 S1P3。GSK 1842799 hydrochloride口服生物利用度高，可快速转化为活性磷酸化形式。口服后，GSK 1842799 hydrochloride可显著降低体内血液淋巴细胞计数。GSK 1842799 hydrochloride在小鼠 EAE 多发性硬化症模型中显示出与 FTY720 相当的疗效。

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GSK 1842799 hydrochloride Chemical Structure

GSK 1842799 hydrochloride Chemical Structure

CAS No. : 1277165-15-7

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GSK 1842799 hydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GSK 1842799 hydrochloride is a selective S1P1 receptor agonist with potent agonist activity and exceptional selectivity over S1P3. GSK 1842799 hydrochloride demonstrates good oral bioavailability and rapid conversion to its active phosphorylated form. GSK 1842799 hydrochloride significantly reduces blood lymphocyte counts in vivo following oral administration. GSK 1842799 hydrochloride has shown efficacy comparable to FTY720 in the mouse EAE model of multiple sclerosis.

分子量

504.44

Formula

C20H30Cl2F3N3O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GSK 1842799 hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK 18427991277165-15-7GSK1842799GSK-1842799OthersInhibitorinhibitorinhibit

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产品名称：
GSK 1842799 hydrochloride
目录号：
HY-16622B
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