2. Epigenetics
  3. Epigenetic Reader Domain
  4. GSK040

GSK040 是一种有效和具有选择性的 BET BD2 抑制剂，pIC50 值为 8.3。GSK040 对 BET BD2 的选择性比 BET BD1 (pIC50=4.6) 高 5000 倍。GSK040 可用于肿瘤学和免疫学疾病的研究。

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GSK040 Chemical Structure

GSK040 Chemical Structure

CAS No. : 2752331-09-0

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GSK040 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GSK040 is a potent and highly selective BET BD2 inhibitor, with a pIC50 of 8.3. GSK040 shows more than 5000-fold selectivity for BET BD2 over BET BD1 (pIC50=4.6). GSK040 can be used for the research of oncology and immunology diseases[1].

IC50 & Target[1]

BD2

8.3 (pIC50)

体内研究
(In Vivo)

GSK040 (1 mg/kg; i.v.) exhibits t1/2 (0.19 h), CLb (50 mL/min/kg) and Vss (0.6 L/kg) in rats[1].
GSK040 (3 mg/kg; p.o.) exhibits oral bioavailability (16%), tmax (0.25 h), Cmax (398 nM) in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

502.60

Formula

C29H34N4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GSK040 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK0402752331-09-0GSK 040GSK-040Epigenetic Reader DomainBETBD2oncologyimmunologyInhibitorinhibitorinhibit

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目录号：
HY-132230
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