2. Immunology/Inflammation Apoptosis
  3. Toll-like Receptor (TLR) IFNAR TNF Receptor
  4. GSK2245035 maleate

GSK2245035 maleate 是一种高效的，选择性的鼻内 Toll-Like 受体 7 (TLR7) 激动剂，具有优先刺激 1 型干扰素 (IFN) 的特性。GSK2245035 maleate 对 IFNα 和TNFα 的 pEC50 分别为 9.3 和 6.5。GSK2245035 maleate 有效抑制人外周血细胞培养物中过敏原诱导的 Th2 细胞因子产生。GSK2245035 maleate 有用于哮喘的潜力。

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GSK2245035 maleate Chemical Structure

GSK2245035 maleate Chemical Structure

CAS No. : 1325212-97-2

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GSK2245035 maleate 的其他形式现货产品:

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GSK2245035 maleate 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

查看 Toll-like Receptor (TLR) 亚型特异性产品:

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

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TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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生物活性

GSK2245035 maleate is a highly potent and selective intranasal Toll-Like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties. GSK2245035 maleate has pEC50s of 9.3 and 6.5 for IFNα and TFNα. GSK2245035 maleate effectively suppresses allergen-induced Th2 cytokine production in human peripheral blood cell cultures. GSK2245035 maleate is used for asthma[1].

分子量

506.60

Formula

C24H38N6O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GSK2245035 maleate 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK22450351325212-97-2GSK 2245035GSK-2245035Toll-like Receptor (TLR)IFNARTNF ReceptorInterferon-α/β receptorInterferon-alpha/beta receptor Tumor Necrosis Factor ReceptorTNFRintranasalpreferentialType-1interferonallergen-inducedTh2cytokineperipheralbloodasthmaInhibitorinhibitorinhibit

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产品名称：
GSK2245035 maleate
目录号：
HY-118250A
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