2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. GW1929 hydrochloride

GW1929 hydrochloride 是有效的、具有口服活性的 PPAR-γ 激动剂，对人 PPAR-γ 的 pKi 为8.84。对人和鼠的 pEC50 分别为 8.56 和 8.27。GW1929 hydrochloride 具有抗糖尿病效果和神经保护作用。GW1929 hydrochloride 抑制神经元细胞凋亡 apoptosis，具有抗炎潜力。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

GW1929 hydrochloride Chemical Structure

GW1929 hydrochloride Chemical Structure

CAS No. : 1217466-21-1

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
5 mg ￥3806
3 - 4 周
10 mg 现货 3 - 4 周
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of GW1929 hydrochloride:

GW1929 hydrochloride 相关抗体

Top Publications Citing Use of Products

    GW1929 hydrochloride purchased from MCE. Usage Cited in: Ecotoxicol Environ Saf. 2020 Sep 15;201:110801.  [Abstract]

    PPARγ agonist (GW 1929) effectively increased the PPARγ expression. Immunofluorescence staining analysis the expression levels of PPARγ in HK2 cells.

    GW1929 hydrochloride purchased from MCE. Usage Cited in: Ecotoxicol Environ Saf. 2020 Sep 15;201:110801.  [Abstract]

    PPARγ agonist (GW 1929) effectively increased the PPARγ expression. Western blotting analysis the expression levels of PPARγ in HK2 cells.

    GW1929 hydrochloride purchased from MCE. Usage Cited in: Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3322-3338.  [Abstract]

    LAZ3 knock-down decreases NRF2 expression and nuclear translocation, while only the PPARa agonist (GW7647) can prevent this inhibition. Both PPARγ agonist (GW1929) and PPARδ agonist (GW0742) can not reverse these inhibitions.

    查看 PPAR 亚型特异性产品:

    查看所有亚型
    PPARα PPARβ/δ PPARγ PPAR PPARδ

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    GW1929 hydrochloride is an orally active peroxisome proliferator-activated receptor-γ (PPARγ) agonist with a pKi of 8.84 for human PPAR-γ, and pEC50s of 8.56 and 8.27 for human PPAR-γ and murine PPAR-γ, respectively. GW1929 hydrochloride has antidiabetic efficacy and neuroprotective potential. GW1929 hydrochloride suppresses neuronal apoptosis and shows anti-inflammatory potential[1][2][3].

    IC50 & Target

    hPPARγ

    8.84 (pKi)

    体外研究
    (In Vitro)

    GW1929 hydrochloride is a potent PPAR-γ activator, with pKis of 8.84, < 5.5, and < 6.5 for human PPAR-γ, PPAR-α, and PPAR-δ, and pEC50s of 8.56 and 8.27 for human PPAR-γ and murine PPAR-γ, respectively[1].
    GW1929 hydrochloride (10 μM) inhibits TBBPA-induced caspase-3 increase and TBBPA-stimulated LDH release in neocortical cell cultures[2]. GW1929 hydrochloride shows significant reduction in the COX-2, iNOS, MMP-9, TNFα and IL-6 levels[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    GW1929 hydrochloride 相关抗体:
    体内研究
    (In Vivo)

    GW1929 hydrochloride (0.5, 1, 5 mg/kg, p.o.) highly decreases nonfasted plasma glucose levels in Zucker diabetic fatty (ZDF) rats after treatment for 14 days, and possesses antilipolytic efficacy[1].
    GW1929 hydrochloride (1, 5 mg/kg, p.o.) increases glucose-stimulated insuline secretion of β-cell in ZDF rats[1]. GW1929 hydrochloride (10 mg/kg body weight) results in amelioration of muscle loss in tumour-bearing mice experimental cachexia[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    532.03

    Formula

    C30H30ClN3O4
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    GW1929 hydrochloride 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    GW19291217466-21-1GW 1929GW-1929PPARPeroxisome proliferator-activated receptorsantidiabetic efficacyneuroprotective potentialanti-inflammatoryCOX-2iNOSMMP-9TNFαIL-6Inhibitorinhibitorinhibit

    您最近查看的产品:

    Your information is safe with us. * Required Fields.

       产品名称：

    		  

    * 需求量：

    * 客户姓名：

    		 

    * Email：

    * 电话：

    		 

    * 公司或机构名称：

       留言给我们：

    Bulk Inquiry

    Inquiry Information

    产品名称：
    GW1929 hydrochloride
    目录号：
    HY-110022
    需求量：

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

       产品名称：

    		  

    * Lot #：

    * 客户姓名：

    		 

    * Email：

       电话：

    		 

    * 部门：

    * 公司或机构名称：

    		 

       留言给我们：

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.

    嗨！很高兴为您提供帮助！

    尊敬的 MCE 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z