2. Cell Cycle/DNA Damage
  3. Deubiquitinase
  4. HBX 28258

HBX 28258 是一种选择性的 USP7 抑制剂，IC50 值为 22.6 μM。HBX 28258 可以共价结合位于 USP7 催化核心的 Cys223，抑制其去泛素化活性，促进 MDM2 蛋白降解，并激活 p53。

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HBX 28258 Chemical Structure

HBX 28258 Chemical Structure

CAS No. : 1426544-54-8

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HBX 28258 相关抗体

Top Publications Citing Use of Products

查看 Deubiquitinase 亚型特异性产品:

查看所有亚型
USP1 USP2 USP7 USP8 USP30 UCHL1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HBX 28258 is a selective USP7 inhibitor, with an IC50 of 22.6 μM. HBX 28258 can covalently binds to Cys223 located in the catalytic core of USP7, inhibits its deubiquitinating activity, promotes MDM2 protein degradation, and activates p53[1].

IC50 & Target[1]

USP7

22.6 μM (IC50)

分子量

435.99

Formula

C26H30ClN3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HBX 28258 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HBX 282581426544-54-8HBX28258HBX-28258DeubiquitinaseDUBsCys223deubiquitinating activityMDM2p53Inhibitorinhibitorinhibit

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目录号：
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