2. Metabolic Enzyme/Protease Apoptosis Immunology/Inflammation NF-κB
  3. Carbonic Anhydrase Apoptosis Reactive Oxygen Species
  4. hCAIX-IN-12

hCAIX-IN-12 是一种有效的 hCAIX 抑制剂，对 CAIX 和 CAII 的 IC50 值分别为 0.74 和 10.78 μM。hCAIX-IN-12 具有抗增殖作用并诱导细胞凋亡 (apoptosis)。hCAIX-IN-12 增加 ROS 的产生。hCAIX-IN-12具有研究结直肠癌（CRC）的潜力。

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hCAIX-IN-12 Chemical Structure

hCAIX-IN-12 Chemical Structure

CAS No. : 2414598-85-7

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hCAIX-IN-12 相关抗体

Top Publications Citing Use of Products

查看 Carbonic Anhydrase 亚型特异性产品:

查看所有亚型
CA CA I CA Ⅱ CA Ⅸ CA XII

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

hCAIX-IN-12 is a potent hCAIX inhibitor with IC50 values of 0.74, 10.78 μM for CAIX and CAII, respectively. hCAIX-IN-12 shows antiproliferative effect and induces apoptosis. hCAIX-IN-12 increases ROS production. hCAIX-IN-12 has the potential for the research of colorectal cancer (CRC) [1].

IC50 & Target

CA Ⅸ

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
6 μM
Compound: 38
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 34530384]
体外研究
(In Vitro)

hCAIX-IN-12 (compound OX27) shows antiproliferative effect with IC50s of 6.0 μM for HCT-116 cells[1].
hCAIX-IN-12 decreases the expression of CAIX in HCT-116 cells and inhibits the expression of CAIX more pronouncedly in hypoxic conditions[1].
hCAIX-IN-12 (0-50 μM; 0-48 h) inhibits the colony formation in a dose-dependent manner and 7 inhibits the migration of HCT-116 cells[1].
hCAIX-IN-12 (6.0 μM; 48 h) induces apoptosis in HCT-116 cells[1].
hCAIX-IN-12 (6.0 μM; 24,48 h) increases in the levels of ROS in HCT-116 cells[1].
hCAIX-IN-12 causes depletion of HCT-116 cells in the G0/G1 (P2 65.21%) phase with an increase in the accumulation of cells in G2/M (P4 18.95%) phase[1].
hCAIX-IN-12 has high binding affinity for CAIX and substantial affinity for HSA[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

hCAIX-IN-12 相关抗体:
分子量

398.46

Formula

C18H14N4O3S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

hCAIX-IN-12 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hCAIX-IN-122414598-85-7Carbonic AnhydraseApoptosisReactive Oxygen SpeciesCarbonate dehydrataseantiproliferativecolony formationmigrationapoptosisHCT-116 cellsROSantioxidantInhibitorinhibitorinhibit

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