2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase
  4. hCAIX-IN-24

hCAIX-IN-24 是一种有效的选择性 hCA IX 抑制剂，KI 值为 32.1 nM。hCAIX-IN-24 具有抗增殖活性。

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hCAIX-IN-24 Chemical Structure

hCAIX-IN-24 Chemical Structure

CAS No. : 3038222-64-6

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hCAIX-IN-24 相关抗体

Top Publications Citing Use of Products

查看 Carbonic Anhydrase 亚型特异性产品:

查看所有亚型
CA CA I CA Ⅱ CA Ⅸ CA XII

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

hCAIX-IN-24 is a potent and selectively hCA IX inhibitor with an KI value of 32.1 nM. hCAIX-IN-24 shows anti-proliferative activity[1].

IC50 & Target

hCA IX

32.1 nM (Ki)

hCA XII

8.1 nM (Ki)

hCA VII

15.9 nM (Ki)

hCA XIII

95.7 nM (Ki)

体外研究
(In Vitro)

hCAIX-IN-24 (compound 7c) (0-100 μM; 24 h) shows anti-proliferative activity with IC50s of 62.5, 0.7121, 12.11, 7.834, 2.356 μM for HDF, MeWo, LN-229, SaOS-2, HepG2 cells, respectively[1].
hCAIX-IN-24 (62.5 μM for NHDF, 2.365 μM for HepG2) induces a significant decrease in O2?- production in NHDF and HepG2 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

hCAIX-IN-24 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: NHDF, MeWo, LN-229, SaOS-2, HepG2 cells
Concentration: 0, 5, 10, 30, 70, 100 μM
Incubation Time: 24 h
Result: Inhibited cell growth with IC50s of 62.5, 0.7121, 12.11, 7.834, 2.356 μM for HDF, MeWo, LN-229, SaOS-2, HepG2 cells, respectively.
分子量

552.11

Formula

C23H24N2O4STe
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

hCAIX-IN-24 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hCAIX-IN-243038222-64-6Carbonic AnhydraseCarbonate dehydrataseanti-proliferativeNHDFHepG2 cellsO2H2O2antitumorInhibitorinhibitorinhibit

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产品名称：
hCAIX-IN-24
目录号：
HY-152001
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