2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. HDAC-IN-42

HDAC-IN-42 (compound 14f) 是一种有效的选择性 HDAC 抑制剂，对 HDAC1 和 HDAC6 的 IC50 值分别为 0.19 和 4.98 µM。HDAC-IN-42 显示出抗癌和抗增殖活性。HDAC-IN-42 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 G2/M 期。

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HDAC-IN-42 Chemical Structure

HDAC-IN-42 Chemical Structure

CAS No. : 2454024-18-9

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HDAC-IN-42 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC-IN-42 (compound 14f) is a potent and selective HDAC inhibitor with IC50 values of 0.19 and 4.98 µM for HDAC1 and HDAC6, respectively. HDAC-IN-42 shows anticancer and anti-proliferative activity. HDAC-IN-42 induces apoptosis and cell cycle arrest at G2/M phase[1].

IC50 & Target[1]

HDAC1

0.19 μM (IC50)

HDAC6

4.98 μM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa IC50
0.23 μM
Compound: 42
Antiproliferative activity against human HeLa cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
[PMID: 34775332]
体外研究
(In Vitro)

HDAC-IN-42 (compound 14f) shows anti-proliferative activity with C50s of 9.56, 13.32, 10.46, 6.91 µM for MCF-7, HCT-116, HepG2, Hela cells, respectively[1].
HDAC-IN-42 (1, 5, 10 µM; 24 h) reduces the colony formation and increases the expression of histone H3 and α-tubulin in HeLa cells[1].
HDAC-IN-42 (1, 5, 10 µM; 48 h) induces apoptosis and cell cycle arrest at G2/M phase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC-IN-42 相关抗体:
分子量

381.34

Formula

C20H15NO7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC-IN-42 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-422454024-18-9HDACApoptosisHistone deacetylasesHeLa cellsapoptosisG2/M phaseanticanceranti-proliferativehistone H3α-tubulinInhibitorinhibitorinhibit

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