2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. HDAC-IN-67

HDAC-IN-67 (compound 27f) 是一种 HDAC 抑制剂，可以抑制 HDAC1 和 HDAC6 的活性，IC50 值分别为 22 nM 和 8 nM。HDAC-IN-67 可以抑制细胞增殖，诱导细胞凋亡 (apoptosis)。HDAC-IN-67 具有抗肿瘤活性。

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HDAC-IN-67 Chemical Structure

HDAC-IN-67 Chemical Structure

CAS No. : 2821923-75-3

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HDAC-IN-67 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC-IN-67 (compound 27f) is an HDAC inhibitor against HDAC1 and HDAC6, with IC50 values of 22 nM and 8 nM, respectively. HDAC-IN-67 inhibits cell proliferation and induces cell apoptosis. HDAC-IN-67 exhibits antitumor activity[1].

IC50 & Target[1]

HDAC6

8 nM (IC50)

HDAC1

22 nM (IC50)

体外研究
(In Vitro)

HDAC-IN-67 在肿瘤细胞 K562，MV4-11，HEL，SU-DHL-2 和 WSU-DLCL-2 中表现出抗增殖活性，IC50 值分别为 4.42 μM，0.79 μM，2.43 μM，1.05 μM 和 1.43 μM[1]。
HDAC-IN-67 诱导 WSU-DLCL-2 细胞凋亡 (10 μM：91.57%；5 μM：77.05%)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC-IN-67 相关抗体:

Cell Proliferation Assay[1]

Cell Line: K562, MV4-11, HEL, SU-DHL-2 and WSU-DLCL-2
Concentration: 5 μM
Incubation Time: 72 h
Result: Exhibited antiproliferative activity.

Apoptosis Analysis[1]

Cell Line: WSU-DLCL-2
Concentration: 5 μM and 10 μM
Incubation Time: 72 h
Result: Induced WSU-DLCL-2 cells apoptosis in a dose-dependent manner (10 μM: 91.57%; 5 μM: 77.05%).
体内研究
(In Vivo)

HDAC-IN-67 (静脉注射，5 mg/kg) 在 ICR 小鼠中的清除率是 65.1 ml/(h·kg)，清除半衰期是 0.361 小时[1]。
HDAC-IN-67 (口服，10 mg/kg) 的口服生物利用度低（F=3.15%）[1]。
HDAC-IN-67 (腹腔注射，50 mg/kg，共 21 天) 在体内具有中等的抗肿瘤效力，TGI 为 31.5%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female ICR mice/antitumour potency[1]
Dosage: i.p., 50 mg/kg once a day for 21 days
Administration: Intraperitoneal injection (i.p.)
Result: Exhibited in vivo antitumorpotency with TGI of 31.5%.
分子量

525.73

Formula

C30H47N5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC-IN-67 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-672821923-75-3HDACApoptosisHistone deacetylaseshistone deacetylaseHDAC1HDAC6K562MV4-11HELSU-DHL-2 WSU-DLCL-2Inhibitorinhibitorinhibit

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产品名称：
HDAC-IN-67
目录号：
HY-157385
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