2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC6-IN-11

HDAC6-IN-11 (Compound 9) 是一种选择性的 HDAC6 抑制剂，IC50 为 20.7 nM，比对其他HDAC 异构体有超过 300 倍的选择性。HDAC6-IN-11 对癌细胞表现出抗增殖活性。

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HDAC6-IN-11 Chemical Structure

HDAC6-IN-11 Chemical Structure

CAS No. : 2409072-27-9

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HDAC6-IN-11 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC6-IN-11 (Compound 9) is a selective HDAC6 inhibitor with the IC50 value of 20.7 nM. HDAC6-IN-11 has more than 300-fold selectivity over HDAC other isoforms. HDAC6-IN-11 shows anti-proliferative activities against cancer cells[1].

IC50 & Target

HDAC6

20.7 nM (IC50)

HDAC8

7750 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 GI50
3.2 μM
Compound: 9
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by Sulforhodamine B assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by Sulforhodamine B assay
[PMID: 31924504]
HCT-116 GI50
1.82 μM
Compound: 9
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by Sulforhodamine B assay
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by Sulforhodamine B assay
[PMID: 31924504]
Sf21 IC50
> 10000 nM
Compound: 9
Inhibition of recombinant human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in Sf21 insect cells by using RHK-K(Ac)-AMC as substrate measured after 60 mins by fluorescence assay
Inhibition of recombinant human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in Sf21 insect cells by using RHK-K(Ac)-AMC as substrate measured after 60 mins by fluorescence assay
[PMID: 31924504]
体外研究
(In Vitro)

HDAC6-IN-11 (0.44-6.68 μM, 48 h) treatment shows anti-proliferative activities against A549 and HCT116 cells[1].
HDAC6-IN-11 (0-20 μM, 48 h) treatment can increase the acetylation status of H3 and tubulin[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC6-IN-11 相关抗体:

Cell Proliferation Assay[1]

Cell Line: A549 and HCT116 cells
Concentration: 0.44-6.68 μM
Incubation Time: 48 hours
Result: Showed anti-proliferative activities to A549 and HCT116 cells (GI50=3.2 and 1.82 μM, respectively).

Western Blot Analysis[1]

Cell Line: HCT116 cells
Concentration: 0, 0.6, 1.25, 2.5, 5, 10 and 20 μM
Incubation Time: 48 hours
Result: Led to the increase of acetylation status of H3 and tubulin in a dose-dependent manner, and upregulated acetylated tubulin.
分子量

336.34

Formula

C19H16N2O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC6-IN-11 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6-IN-112409072-27-9HDACHistone deacetylasesanti-proliferative activityA549HCT116Inhibitorinhibitorinhibit

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