2. Cell Cycle/DNA Damage Epigenetics Anti-infection
  3. HDAC Parasite
  4. HDAC6-IN-27

HDAC6-IN-27 (compound 8C) 是一种 HDAC 抑制剂，对 HDAC6、HDAC8 和 HDAC1 的 IC50 值分别为 15.9 nM、136.5 nM 和 6180.2 nM。HDAC6-IN-27 显示出有效的抗寄生虫作用。

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HDAC6-IN-27 Chemical Structure

HDAC6-IN-27 Chemical Structure

CAS No. : 2758023-91-3

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HDAC6-IN-27 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

查看 Parasite 亚型特异性产品:

查看所有亚型
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC6-IN-27 (compound 8C) is a HDAC inhibitor with IC50 vales of 15.9 nM 136.5 nM and 6180.2 nM for HDAC6, HDAC8 and HDAC1, respectively. HDAC6-IN-27 shows potent antiparasitic effects[1].

IC50 & Target[1]

HDAC6

15.9 nM (IC50)

HDAC8

136.5 nM (IC50)

HDAC6

6180.2 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
22.28 μM
Compound: 8c
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 33668008]
Jurkat IC50
8.03 μM
Compound: 8c
Cytotoxicity against human Jurkat cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human Jurkat cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 33668008]
MCF7 IC50
> 50 μM
Compound: 8c
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 33668008]
NAMALVA IC50
4.79 μM
Compound: 8c
Cytotoxicity against human NAMALVA cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human NAMALVA cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 33668008]
分子量

301.30

Formula

C15H15N3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC6-IN-27 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6-IN-272758023-91-3HDACParasiteHistone deacetylasesHDAC6antiparasitic effectsInhibitorinhibitorinhibit

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产品名称：
HDAC6-IN-27
目录号：
HY-157314
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